Q3AFH3

PR
Gene name
pgi
Protein name
Glucose-6-phosphate isomerase
Names
GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI
Species
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
KEGG Pathway
chy:CHY_0239
EC number
5.3.1.9: Interconverting aldoses and ketoses
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3AFH3

Entry ID Method Resolution Chain Position Source
AF-Q3AFH3-F1 Predicted AlphaFoldDB

No variants for Q3AFH3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3AFH3

No associated diseases with Q3AFH3

3 regional properties for Q3AFH3

Type Name Position InterPro Accession
conserved_site Phosphoglucose isomerase, conserved site 416 - 433 IPR018189
domain Phosphoglucose isomerase, SIS domain 1 58 - 221 IPR035476
domain Phosphoglucose isomerase, SIS domain 2 266 - 439 IPR035482

Functions

Description
EC Number 5.3.1.9 Interconverting aldoses and ketoses
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
carbohydrate derivative binding Binding to a carbohydrate derivative.
glucose-6-phosphate isomerase activity Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.

2 GO annotations of biological process

Name Definition
gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALKIDFNNV FHPYLQKERL GEADIDGYKE KFTSALVSLR EKKEKGELGF FHLPYLPEEE
70 80 90 100 110 120
IAEIEKTARE VREKFKYFVV LGIGGSALGP LAVHTALNNL RYNELSEELR GGPKFYVEDN
130 140 150 160 170 180
IDPERMASLL KVIEPEKTVF NVITKSGATA ETLSQLLIVT EVLKKKVGKR FTEHLIFTTD
190 200 210 220 230 240
PEKGSLRALA RELGVKTFAI PPNVGGRFSE LTPVGLLPAA VTGINIRELL AGAREMAERC
250 260 270 280 290 300
ERENLWENPA GLAAAIHVLL LERGKNMAVM MPYADSLKYM ADWYAQLLGE SIGKRLNRRG
310 320 330 340 350 360
EEVFVGQTPV KALGVTDQHS QVQLYTEGPF DKLLIFLEVE RYRNRVVIPP DFPQYAELKF
370 380 390 400 410 420
LGGHTLNELI IAEKKATEFA LLKARRPNYT VIFPEVNPYT VGELLYFLEA KIAFMGEYLD
430 440 450 460
INAFDQPGVE EGKKATYALL GREGFEEKRQ EVLKVKKEPR FILE