Q3ACT3

PR
Gene name
hemC
Protein name
Porphobilinogen deaminase
Names
PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase
Species
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
KEGG Pathway
chy:CHY_1208
EC number
2.5.1.61: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

247-311 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3ACT3

Entry ID Method Resolution Chain Position Source
AF-Q3ACT3-F1 Predicted AlphaFoldDB

No variants for Q3ACT3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3ACT3

No associated diseases with Q3ACT3

3 regional properties for Q3ACT3

Type Name Position InterPro Accession
domain Porphobilinogen deaminase, N-terminal 6 - 211 IPR022417
domain Porphobilinogen deaminase, C-terminal 226 - 294 IPR022418
binding_site Porphobilinogen deaminase, dipyrromethane cofactor binding site 230 - 246 IPR022419

Functions

Description
EC Number 2.5.1.61 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
hydroxymethylbilane synthase activity Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).

2 GO annotations of biological process

Name Definition
peptidyl-pyrromethane cofactor linkage The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine.
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKEVIVGSR DSALALWQTN WVVERLSKIH PEINFKIVTM KTKGDKILDV ALAKIGDKGL
70 80 90 100 110 120
FTKELEHALL NKTIDMAVHS MKDLPTVLPE GLKIGAFCER EYPGDVFISP KGFKFLELPQ
130 140 150 160 170 180
GARIGTSSLR RIAQILAVRP DLQAIPLRGN LPTRFRKMEE MDLDGIILAY AGVKRLGYED
190 200 210 220 230 240
KITEMLSFDL CLPAVGQGSI GVEIRADDTF IEELLKPIDH FATNRAIRAE RAFLKRLEGG
250 260 270 280 290 300
CQIPIGAYSE VKENRLHLKG VVASLDGKLV IKGEKEGSIE EPEKVGISLA EELLTKGAQK
310
ILEEIRRDAN E