Q3A4P8

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) (Pelobacter carbinolicus)
KEGG Pathway
pca:Pcar_1413
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3A4P8

Entry ID Method Resolution Chain Position Source
AF-Q3A4P8-F1 Predicted AlphaFoldDB

No variants for Q3A4P8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3A4P8

No associated diseases with Q3A4P8

6 regional properties for Q3A4P8

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 420 - 576 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 605 - 651 IPR002300-2
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 691 - 813 IPR013155
domain Methionyl/Leucyl tRNA synthetase 41 - 173 IPR015413
domain Leucyl-tRNA synthetase, editing domain 221 - 407 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEERYDAGGI EGKWQKRWEQ DRTFKAKEKD AREKYYLLEM FPYPSGRIHM GHVRNYSIGD
70 80 90 100 110 120
VVARFKRLQG YNVLHPMGWD AFGMPAENAA IQHKTHPGKW TYENIDNMRA QLKKMGFSYD
130 140 150 160 170 180
WDREVATCHP EYYRWEQLIF LKMLEKGLAY KKSSFVNWCS ECQTVLANEQ VENDACWRCG
190 200 210 220 230 240
TVVEQKELEQ WFFKITDYAQ ELLDDTSKLS GWPEPVLTMQ RNWIGRSTGC EIDFPVADSD
250 260 270 280 290 300
LKIKVFTTRQ DTLYGATFMS LAAEHPLAME LVSAECKAEV EAFIARVRTQ DKAKRTSDDF
310 320 330 340 350 360
VKEGVFTGSY GINPVNGRRI PIYLANFVLM DYGTGAVMAV PTHDQRDFDF ARKYDIPMIV
370 380 390 400 410 420
VIQPEDQTLD PATMTEAWTA PGVLVNSAPF DGLDNESAKE KIAAHLEEQG VGRKTVNYRL
430 440 450 460 470 480
RDWGVSRQRY WGTPIPIIYC PACGIVPVPE EDLPVLLPMD VEISGEGGSP LARHQEFLKV
490 500 510 520 530 540
TCPTCGGDAR RETDTFDTFV ESSWYFARYT CPRFEQGPVD RATVDHWLPV DQYIGGIEHA
550 560 570 580 590 600
VMHLLYARFF TKVMRDLGMM AHDEPFKNLL TQGMVCMETA SCPEHGWLFP EQVVEGKCVL
610 620 630 640 650 660
CGATAQTGRN EKMSKSKKNV VDPDKLILSY GADTARLFSL FAAPPEKDLE WNEQGVEGCY
670 680 690 700 710 720
RFLHRVWRAV YDNLEMISGV AVPASVDGAA RNLRRQVHAT IKKVTGDIDG RFHFNTAIAS
730 740 750 760 770 780
VMELVNAIYG FEAKAQYPGV MREALEATVR LLAPFVPHVC EELWACLGHE GGLEAAGWPA
790 800 810 820 830 840
WDEEALVEDE KTIVVQVNGK VRGKLTIAAD ADNDTVQQAA LKADNVVRFL EGKTVRKVVV
850
VPGRLVNIVV S