Q3A1W0

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) (Pelobacter carbinolicus)
KEGG Pathway
pca:Pcar_2408
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

395-470 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3A1W0

Entry ID Method Resolution Chain Position Source
AF-Q3A1W0-F1 Predicted AlphaFoldDB

No variants for Q3A1W0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3A1W0

No associated diseases with Q3A1W0

4 regional properties for Q3A1W0

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 871 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 657 - 700 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 560 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 713 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTGNEIRSRF LKFFQDHGHT VVPSSALIPH NDPTLLFINA GMNQFKDVFL GREKRDYVRA
70 80 90 100 110 120
TSAQKCVRAG GKHNDLENVG QTARHHTFFE MLGNFSFGDY FKKEAIDHAW KFLTEEMGLP
130 140 150 160 170 180
KDKLWVTVFR EDDEAYDIWR DQQGIPEERL IRMGEKDNFW SMGDTGPCGP CSEILIDQGE
190 200 210 220 230 240
SMSCGDECGI GKCDCDRYLE LWNLVFMQFN RDADGTMTPL PKPSIDTGMG LERITAVMQG
250 260 270 280 290 300
VQSNYDCDLL RGIIAHVEEL SGKRYGDNAE HDMSMRVIAD HSRATAFLIA DGVLPSNEGR
310 320 330 340 350 360
GYVLRRIMRR AARHAKMLGF ADPVLYRTAT FVLQSMAEAY PEPAQRADYV AKIVKIEEER
370 380 390 400 410 420
FIQTLDNGLR ILTEEVERLK AANATVLPGD VAFKLYDTFG FPLDLTADIL RGENVTIDED
430 440 450 460 470 480
GFEACMEEQR QKAREHWKGS GEEAISGIYR QLAEEGARTD FTGYGELTGQ SEILAILLDG
490 500 510 520 530 540
QPVSSAPAGA KVEIVTAATP FYGESGGQTG DCGTLAAGDA EVTITDTKKP LPELFVHVGE
550 560 570 580 590 600
IAAGTLQTGE TATLTVDRER RQATALNHTA THLLQAALVE VLGEHVKQAG SLVTPERLRF
610 620 630 640 650 660
DFIHFSAMSA EELERVETLV NCRIRENAGV DTREMDHEQA VAEGATALFG EKYGDKVRVV
670 680 690 700 710 720
RVGDISMELC GGTHANASGD IGLFKILQET GIAAGVRRIE AVTGAKALQV VRDQERTLDD
730 740 750 760 770 780
LASLIKTDRP QLEARLRKLL ERQKELEREI ESLQGKLNAD QAGDLLQQAT EIDGISVVCG
790 800 810 820 830 840
RVDNLDGKAL RELADQVRDR LSSGVLILGS AHEGKAGLLV AVTKDLTKRL QAGALVKQLA
850 860 870 880
AMVGGGGGGR PDLAQAGGSK PEQLDEALAS VPQRISEALN AA