Q39147
Gene name |
MAG (At3g12040, MEC18.17, T21B14.14, T21B14_115) |
Protein name |
DNA-3-methyladenine glycosylase |
Names |
3-methyladenine DNA glycosidase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G12040 |
EC number |
3.2.2.21: Hydrolyzing N-glycosyl compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q39147
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q39147-F1 | Predicted | AlphaFoldDB |
20 variants for Q39147
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00318562 | 8 | S>T | No | 1000Genomes | |
| ENSVATH13902763 | 20 | V>I | No | 1000Genomes | |
| tmp_3_3836721_T_C | 21 | T>A | No | 1000Genomes | |
| ENSVATH00318561 | 22 | T>A | No | 1000Genomes | |
| ENSVATH05814482 | 22 | T>N | No | 1000Genomes | |
| ENSVATH00318560 | 23 | R>Q | No | 1000Genomes | |
| tmp_3_3836670_C_T | 38 | A>T | No | 1000Genomes | |
| ENSVATH10624765 | 41 | V>G | No | 1000Genomes | |
| tmp_3_3836657_C_T | 42 | R>K | No | 1000Genomes | |
| ENSVATH13902762 | 43 | P>H | No | 1000Genomes | |
| tmp_3_3836624_T_G | 53 | E>A | No | 1000Genomes | |
| ENSVATH02135731 | 65 | Q>L | No | 1000Genomes | |
| ENSVATH02135727 | 134 | L>F | No | 1000Genomes | |
| tmp_3_3835622_G_A | 196 | L>F | No | 1000Genomes | |
| ENSVATH13902761 | 199 | P>R | No | 1000Genomes | |
| tmp_3_3835443_T_A | 224 | Y>F | No | 1000Genomes | |
| tmp_3_3835434_G_A | 227 | P>L | No | 1000Genomes | |
| tmp_3_3835410_C_G | 235 | R>T | No | 1000Genomes | |
| ENSVATH13902760 | 238 | V>I | No | 1000Genomes | |
| tmp_3_3835396_C_A | 240 | D>Y | No | 1000Genomes |
No associated diseases with Q39147
No regional properties for Q39147
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q39147 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.2.2.21 | Hydrolyzing N-glycosyl compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| alkylbase DNA N-glycosylase activity | Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-3-methyladenine glycosylase activity | Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. |
| DNA-3-methylguanine glycosylase activity | Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site. |
| DNA-7-methyladenine glycosylase activity | Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site. |
| DNA-7-methylguanine glycosylase activity | Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| base-excision repair | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKTPARRSKR | VNQEESETNV | TTRVVLRTRK | TNCSKTRAAR | VRPDYPLTRT | TSESEMKLMP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PEFFQIDALD | LAPRLLGKFM | RRDNVVLRIT | EVEAYRPNDS | ACHGRFGVTP | RTAPVFGPGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HAYVYLCYGL | HMMLNIVADK | EGVGAAVLIR | SCSPVSGMET | IQERRGLKTD | KPVLLNGPGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VGQALGLSTE | WSHHPLYSPG | GLELLDGGED | VEKVMVGPRV | GIDYALPEHV | NALWRFAVAD |
| 250 | |||||
| TPWISAPKNT | LKPL |