Q38YN9

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei subsp. sakei)
KEGG Pathway
lsa:LCA_0387
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

393-481 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q38YN9

Entry ID Method Resolution Chain Position Source
AF-Q38YN9-F1 Predicted AlphaFoldDB

No variants for Q38YN9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q38YN9

No associated diseases with Q38YN9

4 regional properties for Q38YN9

Type Name Position InterPro Accession
domain DHHA1 domain 738 - 877 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 657 - 700 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 553 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 713 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKQLTSAQVR QMFLDFFKEK GHDVEPSASL IPDEDPTLLW INSGVATLKK YFDGRVVPNN
70 80 90 100 110 120
PRITNAQKSI RTNDIENVGK TARHHTFFEM LGNFSVGDYF KEDAIPWAWE FLTSDKWIGL
130 140 150 160 170 180
DPEKLYVTVY PKDKDAHRIW HEKVGLAEDR IIEVEDNFWD IGEGPCGPDS EIFYDRGQSF
190 200 210 220 230 240
NNVSEDDPEN YPGGENERYL EVWNIVFSEF NHLPNGEYVE QPHKNIDTGM GLERLVSVIQ
250 260 270 280 290 300
EAPTNFETDL FMPLIEATAA MSDHKQYGQN AADDISFKII ADHARAVTFA IGDGAMPANE
310 320 330 340 350 360
GRGYVLRRLI RRAILNGKKL GINDAFMYKL VPIVGEIMHS YYPDVLEQKD FIEKVIRSEE
370 380 390 400 410 420
DRFRETLNDG LRLLNQTIEA VKAENETEIN GADAFKLFDT FGFPIELTTE YAEDEGLTVD
430 440 450 460 470 480
QAGFEKEMAA QKARARNARS DEQSMGSQNE VLLNIKTKSE FTGYSELETE SRLADIIQDN
490 500 510 520 530 540
AEQESVTTGV AQLVFEATPF YAEMGGQVAD QGIIKNLAGQ VVAEVTDVQY APNGQPLHTV
550 560 570 580 590 600
KVLKEMISGV HYTLSVDPTF RGGVVKNHTA THLLDQALRD VLGEHTHQAG SLVEPDYLRF
610 620 630 640 650 660
DFTNLGQVTP DQLAEVEQIV NDKIWAALPV NTVETDIETA KQMGAIALFT EKYGKTVRVV
670 680 690 700 710 720
QIGDYSMELC GGTHANNTSD LGLFKITSES GIGAGTRRIE AVTSKAAFKY LNDKQVLLNE
730 740 750 760 770 780
LASELKVAQT KDLPKKIQQL QADLKAEQKE NEQLKAKFAQ EQAGNVFENV VEAGQWRLVA
790 800 810 820 830 840
ADAKVAGMNE LRQLADQWQQ KQISDVLVLA TVAGDKVSLI VAVAPDAIKA GIKAGDLIKQ
850 860 870
IAPLVGGGGG GRPDMAQAGG KNPAGIPDAL AAAKEFLA