Q38PR2

PR
Gene name
MT-ND5 (MTND5, NADH5, ND5)
Protein name
NADH-ubiquinone oxidoreductase chain 5
Names
NADH dehydrogenase subunit 5
Species
Mammuthus primigenius (Siberian woolly mammoth)
KEGG Pathway
EC number
7.1.1.2: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

546-603 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q38PR2

Entry ID Method Resolution Chain Position Source
AF-Q38PR2-F1 Predicted AlphaFoldDB

No variants for Q38PR2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q38PR2

No associated diseases with Q38PR2

3 regional properties for Q38PR2

Type Name Position InterPro Accession
domain NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal 68 - 118 IPR001516
domain NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit 134 - 413 IPR001750
domain NADH dehydrogenase subunit 5, C-terminal 422 - 601 IPR010934

Functions

Description
EC Number 7.1.1.2 Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
respirasome The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

1 GO annotations of molecular function

Name Definition
NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).

2 GO annotations of biological process

Name Definition
mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.
mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNPISTLTLA SLIILTLPIT TTLLQNNKTN CFLYITKTAV TYAFVISLIP TLLFVQSNQE
70 80 90 100 110 120
AYISNWHWMT IHTLKLSLSF KLDFFSLTFM PIALFITWSI MEFSLWYMHS DPHINRFFKY
130 140 150 160 170 180
LLLFLITMLI LVSANNLLQL FMGWEGVGIM SFLLISWWHG RTDANTAALQ AMLYNRIGDM
190 200 210 220 230 240
GFIMMMAWFI IHLNSWEFQQ IFLTNPKNTT LPLLGLLLAS TGKSAQFGLH PWLPSAMEGP
250 260 270 280 290 300
TPVSALLHSS TMVMAGVFTL IRFYPLMENN LTVQTSTLCL GAITTLFTAI CALTQNDIKK
310 320 330 340 350 360
IIALSTSSQL GLMMVTIGIN QPHLAFTHMC THAFFKAMLF LSSGSIIHNL DNEQDIRKMG
370 380 390 400 410 420
GLYKTMPITS TAIIIGSLAL TGMPFLTGFY SKDPIIETAN MSYINTWALL VTLIAVSMTA
430 440 450 460 470 480
SYSTRIIFFA LLGQPRYPTL TRINENNPHL VNPIKRLILG SIFMGFFISM NTIPHTTPQM
490 500 510 520 530 540
TMPPHLKFMA LAVTLLGFTV ATELNNMTHN LMFKQPSRMY TFSTTLGYYP TTTHRILPYL
550 560 570 580 590 600
SLTMSQNLAT TIMDSIWLEK MIPKNLTTMQ KTAASLVSNQ KGLMKLYFLS FLLSITLGLL
IAL