Q38E53
Gene name |
SLS1 |
Protein name |
Phosphatidylinositol:ceramide inositolphosphotransferase |
Names |
Inositol-phosphorylceramide synthase, IPC synthase, Sphingolipid synthase |
Species |
Trypanosoma brucei brucei (strain 927/4 GUTat101) |
KEGG Pathway |
tbr:Tb09.211.1030 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q38E53
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q38E53-F1 | Predicted | AlphaFoldDB |
No variants for Q38E53
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q38E53 | |||||
No associated diseases with Q38E53
1 regional properties for Q38E53
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sphingomyelin synthase-like domain | 219 - 291 | IPR025749 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of Golgi membrane | The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ceramide cholinephosphotransferase activity | Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| sphingomyelin synthase activity | Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| ceramide biosynthetic process | The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| sphingomyelin biosynthetic process | The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MISYPFFSLS | PPGLVPPPMA | VPPVEMYSGS | FWNRMRKPLP | LRTQVIRFTV | VFVIVSFILA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VALQITHERM | PDPKVTKPLP | DLGFELLTKI | SFLSVVTDVL | IAFLSSLSFF | TLWKLYLLHR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HCVGSGEPEL | PCNIPGVSRF | FLSVWLCKEN | CRIELRNVHT | IAWIRFITSY | ALLLLFRSLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IVMTSMPTPV | DKCQNPPKIE | NPVKNVILTV | LTAGGGSIHC | GDLMYSGHTV | ILTLHLMFHW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IYGAMVHWSF | RPVVTVVAIF | GYYCIVASRS | HYTDDVLVAI | YLTIATFIAV | GHNADGAPWQ |
| 310 | 320 | 330 | 340 | 350 | |
| LQLFIRWLPC | CGANSREVTE | DSQPVMVAFK | SEAVDELRER | DDSAGLSCEV | STNEV |