Q38899

PR
Gene name
ORC2
Protein name
Origin of replication complex subunit 2
Names
AtORC2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G37560
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q38899

Entry ID Method Resolution Chain Position Source
AF-Q38899-F1 Predicted AlphaFoldDB

23 variants for Q38899

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_15759594_A_C 9 E>D No 1000Genomes
ENSVATH13562138 11 E>D No 1000Genomes
tmp_2_15759608_T_G 14 F>C No 1000Genomes
tmp_2_15759661_G_T 32 A>S No 1000Genomes
tmp_2_15759699_G_T 44 Q>H No 1000Genomes
ENSVATH13562140 66 S>T No 1000Genomes
ENSVATH13562141 73 S>L No 1000Genomes
ENSVATH14593406 81 C>Y No 1000Genomes
tmp_2_15760007_C_G 86 L>V No 1000Genomes
tmp_2_15760245_G_T 125 V>F No 1000Genomes
ENSVATH00263486 170 Q>L No 1000Genomes
tmp_2_15760456_C_T 195 S>L No 1000Genomes
tmp_2_15760483_C_T 204 S>F No 1000Genomes
tmp_2_15760512_A_G 214 I>V No 1000Genomes
ENSVATH13562150 220 P>S No 1000Genomes
tmp_2_15760689_T_G 222 L>W No 1000Genomes
tmp_2_15760788_T_A 255 V>D No 1000Genomes
ENSVATH14593408 270 I>T No 1000Genomes
ENSVATH00263487 279 G>A No 1000Genomes
tmp_2_15760890_A_G 289 Y>C No 1000Genomes
tmp_2_15760922_C_T 300 P>S No 1000Genomes
ENSVATH14593409 339 S>C No 1000Genomes
ENSVATH05672478 342 Q>L No 1000Genomes

No associated diseases with Q38899

No regional properties for Q38899

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q38899

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome.

1 GO annotations of molecular function

Name Definition
DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q10QS7 ORC2 Origin of replication complex subunit 2 Oryza sativa subsp japonica (Rice) PR
10 20 30 40 50 60
MEDIENIEED EYGFSRNYFL AKELGGASKR SAHKLSDIHI VDEQELRETA STIEMKHSKE
70 80 90 100 110 120
ISELMSDYKT MYSKWVFELR CGFGLLMYGF GSKKALVEDF ASASLTDYSV VVINGYLPSV
130 140 150 160 170 180
NLKQVLLALA ELLSELLKCK RKSSGSLSKG QETFPSRSMD DILSFLHGPQ SGDKDCFICV
190 200 210 220 230 240
VVHNIDGPAL RDPESQQTLA RLSSCSHIRL VASIDHVNAP LLWDKKMVHK QFNWLWHHVP
250 260 270 280 290 300
TFAPYNVEGV FFPLVLAQGS TAQTAKTAAI VLQSLTPNGQ NVFKILAEYQ LSHPDEDGMP
310 320 330 340 350 360
TDDLYSASRE RFFVSSQVTL NSHLTEFKDH ELVKTKRNSD GQECLNIPLT SDAIRQLLLD
LNQ