AiPD: Autoinhibited Protein Database

Gene name	XPB1 (XPB, At5g41370, MYC6.8)
Protein name	General transcription and DNA repair factor IIH helicase subunit XPB1
Names	TFIIH subunit XPB, ERCC3 homolog 1, Protein araXPB, RAD25 homolog 1, AtXPB1, XPB homolog 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G41370
EC number	3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-71 (Predicted disordered autoinhibitory region) PR

1-71 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q38861-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH03309634	21	Q>E	No	1000Genomes
tmp_5_16551581_A_G	21	Q>R	No	1000Genomes
ENSVATH07289217	36	A>T	No	1000Genomes
tmp_5_16551845_C_T	82	L>F	No	1000Genomes
tmp_5_16552115_G_T	144	E>D	No	1000Genomes
ENSVATH03309637	164	R>Q	No	1000Genomes
ENSVATH03309660	194	Y>C	No	1000Genomes
ENSVATH03309661	204	R>K	No	1000Genomes
ENSVATH00693237	206	C>S	No	1000Genomes
ENSVATH14560823	214	G>R	No	1000Genomes
ENSVATH03309662	218	N>H	No	1000Genomes
ENSVATH12320694	223	A>V	No	1000Genomes
tmp_5_16552788_G_A	224	A>T	No	1000Genomes
ENSVATH14560846	237	D>N	No	1000Genomes
ENSVATH12320788	249	L>F	No	1000Genomes
ENSVATH07289241	294	F>V	No	1000Genomes
ENSVATH14560849	320	A>V	No	1000Genomes
tmp_5_16553948_G_A	432	G>E	No	1000Genomes
ENSVATH07289261	471	N>H	No	1000Genomes
tmp_5_16554541_G_A	510	R>K	No	1000Genomes
ENSVATH12320834	521	Q>K	No	1000Genomes
tmp_5_16554574_A_G	521	Q>R	No	1000Genomes
ENSVATH07289276	620	E>V	No	1000Genomes
ENSVATH14560856	648	S>L	No	1000Genomes
tmp_5_16555500_C_A	671	P>Q	No	1000Genomes
ENSVATH07289280	672	D>E	No	1000Genomes
ENSVATH12320958	674	G>D	No	1000Genomes
tmp_5_16555544_T_A	686	L>M	No	1000Genomes
tmp_5_16555609_A_C	707	E>D	No	1000Genomes
ENSVATH12320961	725	S>N	No	1000Genomes
tmp_5_16555671_C_A	728	S>Y	No	1000Genomes
ENSVATH07289283	732	G>E	No	1000Genomes
tmp_5_16555737_A_C	750	K>T	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Helicase, C-terminal	510 - 676	IPR001650
domain	Helicase/UvrB, N-terminal	281 - 437	IPR006935
domain	Helicase superfamily 1/2, ATP-binding domain	278 - 459	IPR014001
domain	ERCC3/RAD25/XPB helicase, C-terminal domain	463 - 710	IPR032438
domain	Helicase XPB/Ssl2, N-terminal domain	66 - 188	IPR032830

		Description
EC Number	3.6.4.12	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleotide-excision repair factor 3 complex	One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIIH holo complex	A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.
transcription preinitiation complex	A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.

Name	Definition
3'-5' DNA helicase activity	Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Name	Definition
nucleotide-excision repair, DNA incision	A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound.
response to UV	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
transcription initiation at RNA polymerase II promoter	A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P19447	ERCC3	General transcription and DNA repair factor IIH helicase subunit XPB	Homo sapiens (Human)	PR