AiPD: Autoinhibited Protein Database

Q32NC0

Gene name	C18orf21 (XTP13, PNAS-124, PNAS-131)
Protein name	UPF0711 protein C18orf21
Names	HBV X-transactivated gene 13 protein, HBV XAg-transactivated protein 13
Species	Homo sapiens (Human)
KEGG Pathway	hsa:83608
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

90-201 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

90-201 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q32NC0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q32NC0-F1	Predicted				AlphaFoldDB

187 variants for Q32NC0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA8938431 rs748289475	3	Q>*		No	ClinGen ExAC gnomAD
CA402288781 rs1257040412	3	Q>H		No	ClinGen gnomAD
CA8938432 rs772383831	3	Q>P		No	ClinGen ExAC gnomAD
rs960410701 CA298807379	5	H>Q		No	ClinGen TOPMed gnomAD
CA298807378 rs780863722	5	H>Y		No	ClinGen TOPMed gnomAD
CA402288803 rs761151882	6	Y>*		No	ClinGen ExAC gnomAD
CA402288797 rs1158609875	6	Y>N		No	ClinGen TOPMed
rs766926524 CA402288805	7	L>F		No	ClinGen ExAC TOPMed gnomAD
CA8938435 rs766926524	7	L>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	7	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766926524 CA8938436	7	L>V		No	ClinGen ExAC TOPMed gnomAD
CA8938437 rs760174508	8	E>A		No	ClinGen ExAC gnomAD
CA402288818 rs1195905200	9	A>T		No	ClinGen gnomAD
TCGA novel	11	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8938438 rs764832634	12	R>Q		No	ClinGen ExAC gnomAD
rs752289559 CA402288839	13	G>*		No	ClinGen ExAC TOPMed gnomAD
CA298807380 rs199497571	13	G>E		No	ClinGen 1000Genomes
rs752289559 CA8938439	13	G>R		No	ClinGen ExAC TOPMed gnomAD
CA8938440 rs762465890	14	L>V		No	ClinGen ExAC gnomAD
rs763840961 CA8938441	15	H>Q		No	ClinGen ExAC gnomAD
CA402288850 rs1395543849	15	H>R		No	ClinGen gnomAD
CA402288858 rs1359720452	16	D>E		No	ClinGen gnomAD
rs541952483 CA8938442	16	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1457557072 CA402288873	18	C>F		No	ClinGen TOPMed gnomAD
TCGA novel	20	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1208309060 CA402288890	21	Q>E		No	ClinGen TOPMed
CA402288912 rs1285092255	24	Y>C		No	ClinGen TOPMed
CA402288908 rs1442036375	24	Y>H		No	ClinGen TOPMed
rs1008605058 CA298807383	27	W>R		No	ClinGen Ensembl
CA8938468 rs755994591	28	A>T		No	ClinGen ExAC TOPMed gnomAD
rs780070613 CA8938469	28	A>V		No	ClinGen ExAC TOPMed gnomAD
CA402288963 rs1210757999	30	T>I		No	ClinGen TOPMed
CA402288959 rs1288209357	30	T>P		No	ClinGen gnomAD
CA402288967 rs61731892	31	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8938471 rs61731892	31	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8938470 rs61731892	31	S>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs899817680 CA298807384	32	S>L		No	ClinGen TOPMed gnomAD
CA8938473 rs747226938	33	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA8938501 rs200500810	34	D>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8938502 rs200500810	34	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8938474 rs771315707	34	D>H		No	ClinGen ExAC TOPMed gnomAD
CA402289002 rs773804151	35	D>G		No	ClinGen ExAC TOPMed gnomAD
CA8938503 rs773804151	35	D>V		No	ClinGen ExAC TOPMed gnomAD
CA8938504 rs377220879	37	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA402289030 rs1161451763	39	F>S		No	ClinGen TOPMed
CA8938505 rs771645096	41	E>Q		No	ClinGen ExAC gnomAD
rs772864488 CA8938506	42	T>A		No	ClinGen ExAC gnomAD
CA8938507 rs760303447	42	T>M		No	ClinGen ExAC gnomAD
rs1216238167 CA402289059	43	C>*		No	ClinGen gnomAD
CA402289058 rs1341640765	43	C>F		No	ClinGen gnomAD
CA8938510 rs759491873	45	Y>*		No	ClinGen ExAC gnomAD
CA8938511 rs765286224	46	C>R		No	ClinGen ExAC gnomAD
CA298807615 rs895551202	47	F>S		No	ClinGen Ensembl
rs751625003 CA8938512	48	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA402289109 rs1487092804	51	V>L		No	ClinGen gnomAD
CA402289116 rs1192077645	52	L>P		No	ClinGen gnomAD
CA8938517 rs756331250	53	D>G		No	ClinGen ExAC TOPMed gnomAD
rs767767004 CA8938515	53	D>N		No	ClinGen ExAC gnomAD
CA8938516 rs756331250	53	D>V		No	ClinGen ExAC TOPMed gnomAD
rs767767004 CA8938514	53	D>Y		No	ClinGen ExAC gnomAD
rs1425032618 CA402289132	55	S>A		No	ClinGen gnomAD
CA402289135 rs1435908893	55	S>F		No	ClinGen gnomAD
CA402289137 rs1175891729	56	R>*		No	ClinGen gnomAD
rs755473253 CA298807616	56	R>P		No	ClinGen ExAC gnomAD
rs755473253 CA8938519	56	R>Q		No	ClinGen ExAC gnomAD
rs779395246 CA8938520	58	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8938521 rs747598157	58	R>H		No	ClinGen ExAC gnomAD
CA8938522 rs771557269	59	L>R		No	ClinGen ExAC
rs1434306890 CA402289190	65	L>V		No	ClinGen gnomAD
rs1274372798 CA402289205	67	P>L		No	ClinGen gnomAD
CA402289204 rs1394942587	67	P>S		No	ClinGen TOPMed gnomAD
rs772772389 CA8938523	68	K>Q		No	ClinGen ExAC
CA8938524 rs202045982	75	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA402289260 rs1234995281	75	R>Q		No	ClinGen gnomAD
CA8938525 rs770535824	77	A>V		No	ClinGen ExAC TOPMed gnomAD
CA402289278 rs1204173213	78	R>K		No	ClinGen gnomAD
rs1367158060 CA402289285	79	N>D		No	ClinGen TOPMed
rs759256953 CA8938527	79	N>T		No	ClinGen ExAC gnomAD
CA8938528 rs769799976	80	Y>C		No	ClinGen ExAC gnomAD
rs922479266 CA402289298	81	T>A		No	ClinGen TOPMed
rs922479266 CA298807618	81	T>P		No	ClinGen TOPMed
rs763054569 CA8938530	82	L>H		No	ClinGen ExAC gnomAD
CA402289333 rs1598576360	86	E>A		No	ClinGen Ensembl
rs1005447386 CA298807620	86	E>K		No	ClinGen Ensembl
CA8938532 rs371032567	87	A>P		No	ClinGen ESP ExAC gnomAD
CA8938531 rs371032567	87	A>T		No	ClinGen ESP ExAC gnomAD
CA402289356 rs1453419658	89	M>I		No	ClinGen gnomAD
CA8938533 rs760906424	89	M>L		No	ClinGen ExAC gnomAD
rs1172614896 CA402289353	89	M>T		No	ClinGen TOPMed
CA402289359 rs1159511936	90	V>L		No	ClinGen gnomAD
rs1426754715 CA402289369	91	K>I		No	ClinGen TOPMed
CA8938534 rs766544330	94	K>E		No	ClinGen ExAC gnomAD
CA402289399 rs1419431662	95	D>G		No	ClinGen TOPMed
CA8938535 rs754162040	97	K>R		No	ClinGen ExAC
CA8938536 rs755346519	100	L>S		No	ClinGen ExAC gnomAD
CA8938553 rs759817593	101	L>F		No	ClinGen ExAC gnomAD
rs1242141880 CA402289453	102	I>L		No	ClinGen gnomAD
rs1598578006 CA402289465	103	T>I		No	ClinGen Ensembl
CA8938555 rs765555167	105	K>E		No	ClinGen ExAC gnomAD
rs1381247071 CA402289485	106	T>I		No	ClinGen gnomAD
rs200115196 CA402289482	106	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200115196 CA8938556	106	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761190396 CA8938558	107	C>W		No	ClinGen ExAC TOPMed gnomAD
rs758852843 CA8938557	107	C>Y		No	ClinGen ExAC
CA402289496 rs1196930361	108	N>S		No	ClinGen gnomAD
CA8938559 rs751025528	109	R>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8938560 rs756710700	109	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	111	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	112	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745485657 CA8938563	113	H>L		No	ClinGen ExAC gnomAD
rs780822015 CA8938562	113	H>Y		No	ClinGen ExAC gnomAD
rs769623390 CA402289557	117	S>I		No	ClinGen ExAC TOPMed gnomAD
CA8938564 rs769623390	117	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1253810654 CA402289560	118	R>G		No	ClinGen TOPMed
rs1187574111 CA402289562	118	R>K		No	ClinGen TOPMed
rs779949649 CA402289573	119	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1465151211 CA402289596	123	T>A		No	ClinGen TOPMed gnomAD
rs1024914305 CA298807853	123	T>I		No	ClinGen TOPMed gnomAD
rs774167045 CA8938568	124	L>F		No	ClinGen ExAC gnomAD
CA8938567 rs768650028	124	L>S		No	ClinGen ExAC TOPMed gnomAD
rs748172036 CA8938569	125	K>E		No	ClinGen ExAC gnomAD
CA402289611 rs1355640718	125	K>N		No	ClinGen gnomAD
CA8938570 rs770907932	126	S>N		No	ClinGen ExAC gnomAD
CA8938572 rs759731869 CA402289616	126	S>R		No	ClinGen ExAC gnomAD
CA8938571 rs770907932	126	S>T		No	ClinGen ExAC gnomAD
CA8938574 rs765466245	127	N>I		No	ClinGen ExAC gnomAD
rs765466245 CA8938573	127	N>T		No	ClinGen ExAC gnomAD
CA402289624 rs1228779978	128	P>A		No	ClinGen gnomAD
CA402289630 rs1253538961	129	A>P		No	ClinGen gnomAD
CA402289639 rs1320369450	130	T>I		No	ClinGen TOPMed
CA402289646 rs1598578162	131	P>L		No	ClinGen Ensembl
CA8938578 VAR_030903 rs2276314	132	T>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA298807854 rs902816091	132	T>I		No	ClinGen TOPMed
CA402289648 rs2276314	132	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs552186605 CA8938579	137	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8938580 rs766915346	138	K>N		No	ClinGen ExAC TOPMed gnomAD
rs148863953 CA8938581	140	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA298807856 rs919998932	141	E>D		No	ClinGen Ensembl
rs755791233 CA8938583	142	R>G		No	ClinGen ExAC gnomAD
CA8938584 rs201951096	144	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA402289723 rs201951096	144	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1374680935 CA402289734	146	N>H		No	ClinGen gnomAD
CA402289741 rs1366583919	146	N>K		No	ClinGen TOPMed
rs1432805099 CA402289758	149	H>D		No	ClinGen gnomAD
rs749036138 CA8938585	151	M>T		No	ClinGen ExAC TOPMed gnomAD
CA402289773 rs1375882369	151	M>V		No	ClinGen TOPMed gnomAD
CA402289790 rs1286820099	153	G>A		No	ClinGen gnomAD
CA402289789 rs1286820099	153	G>D		No	ClinGen gnomAD
CA402289787 rs1191745660	153	G>R		No	ClinGen TOPMed
rs1382232312 CA402289797	154	S>L		No	ClinGen gnomAD
rs1007761068 CA298807857	155	K>N		No	ClinGen TOPMed
TCGA novel	155	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	158	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402289828 rs1487801036	159	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs143556172 CA8938590	161	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA402289844 rs1279753324	162	V>I		No	ClinGen TOPMed
CA402289858 rs1404371013	164	R>G		No	ClinGen TOPMed
CA402289891 rs1253476312	166	P>R		No	ClinGen gnomAD
rs189214391 CA8938608	167	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA402289906 rs1175219204	168	S>A		No	ClinGen gnomAD
CA298807994 rs1018844108	175	C>F		No	ClinGen TOPMed gnomAD
CA402289971 rs1160909460	175	C>W		No	ClinGen gnomAD
rs762264289 CA298807995	179	N>T		No	ClinGen Ensembl
rs372712333 CA8938612	181	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8938611 rs749449588	181	S>T		No	ClinGen ExAC gnomAD
CA402290024 rs1430715542	182	K>E		No	ClinGen gnomAD
TCGA novel	182	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402290049 rs1199601342	184	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA402290062 rs1440708585	186	H>P		No	ClinGen gnomAD
CA402290063 rs1440708585	186	H>R		No	ClinGen gnomAD
CA8938613 rs774544109	193	L>V		No	ClinGen ExAC gnomAD
CA8938614 rs762246199	197	N>S		No	ClinGen ExAC gnomAD
rs982291041 CA298807996	199	S>A		No	ClinGen TOPMed
CA402290181 rs1233932820	200	Q>H		No	ClinGen gnomAD
rs1275151655 CA402290191	202	I>L		No	ClinGen gnomAD
CA8938615 rs772403832	202	I>M		No	ClinGen ExAC TOPMed gnomAD
CA8938616 rs773845572	204	K>E		No	ClinGen ExAC gnomAD
CA8938617 rs761329617	205	V>M		No	ClinGen ExAC gnomAD
TCGA novel	206	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402290228 rs1169598830	207	F>Y		No	ClinGen gnomAD
rs1325317939 CA402290239	209	N>D		No	ClinGen TOPMed
rs1178731722 CA402290255	211	L>V		No	ClinGen gnomAD
TCGA novel	214	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8938619 rs765953729	216	G>S		No	ClinGen ExAC gnomAD
TCGA novel	217	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA298807997 rs377292504	217	G>A		No	ClinGen ESP
rs928095344 CA298807998	218	L>P		No	ClinGen Ensembl

No associated diseases with Q32NC0

2 regional properties for Q32NC0

Type	Name	Position	InterPro Accession
domain	Geminivirus AL1 replication-associated protein, catalytic domain	10 - 116	IPR022690
domain	Geminivirus AL1 replication-associated protein, central domain	131 - 239	IPR022692

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MRQKHYLEAA	ARGLHDSCPG	QARYLLWAYT	SSHDDKSTFE	ETCPYCFQLL	VLDNSRVRLK
70	80	90	100	110	120
PKARLTPKIQ	KLLNREARNY	TLSFKEAKMV	KKFKDSKSVL	LITCKTCNRT	VKHHGKSRSF
130	140	150	160	170	180
VSTLKSNPAT	PTSKLSLKTP	ERRTANPNHD	MSGSKGKSPA	SVFRTPTSGQ	SVSTCSSKNT
190	200	210
SKTKKHFSQL	KMLLSQNESQ	KIPKVDFRNF	LSSLKGGLLK