Q32LQ4

PR
Gene name
bhmt (wu:fb53h01, zgc:123027)
Protein name
Betaine--homocysteine S-methyltransferase 1
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:322228
EC number
2.1.1.5: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

334-400 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q32LQ4

Entry ID Method Resolution Chain Position Source
AF-Q32LQ4-F1 Predicted AlphaFoldDB

No variants for Q32LQ4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q32LQ4

No associated diseases with Q32LQ4

12 regional properties for Q32LQ4

Type Name Position InterPro Accession
domain Bromodomain 1333 - 1441 IPR001487
domain Zinc finger, RING-type 1187 - 1232 IPR001841
domain Zinc finger, PHD-type 1186 - 1232 IPR001965
domain WSTF/Acf1/Cbp146 20 - 126 IPR013136
conserved_site Bromodomain, conserved site 1357 - 1414 IPR018359
domain DDT domain 605 - 669 IPR018501
conserved_site Zinc finger, PHD-type, conserved site 1187 - 1231 IPR019786
domain Zinc finger, PHD-finger 1184 - 1234 IPR019787
domain WHIM2 domain 900 - 1024 IPR028941
domain WHIM1 domain 728 - 768 IPR028942
domain Tyrosine-protein kinase BAZ1B, bromodomain 1340 - 1436 IPR037375
domain Tyrosine-protein kinase BAZ1B, PHD finger 1186 - 1231 IPR047256

Functions

Description
EC Number 2.1.1.5 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
betaine-homocysteine S-methyltransferase activity Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine.
zinc ion binding Binding to a zinc ion (Zn).

6 GO annotations of biological process

Name Definition
amino-acid betaine catabolic process The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid.
digestive system development The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
L-methionine salvage Any process that generates L-methionine from derivatives of it, without de novo synthesis.
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.
type B pancreatic cell development The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q99707 MTR Methionine synthase Homo sapiens (Human) PR
Q93088 BHMT Betaine--homocysteine S-methyltransferase 1 Homo sapiens (Human) PR
Q09582 metr-1 Probable methionine synthase Caenorhabditis elegans PR
10 20 30 40 50 60
MAPVGSKRGV LERLNAGEVV IGDGGFVFAL EKRGYVKAGP WTPEAAAEHP EAVRQLHREF
70 80 90 100 110 120
LRAGSNVMQT FTFYASDDKL ENRGNKLSFT GQQINEAACD LAREVANEGD ALVAGGVSQT
130 140 150 160 170 180
PSYLSCKSEE EVKKTFKKQL DVFIKKNVDL LIAEYFEHVE EAEWAVQVLK ATGKPVAATL
190 200 210 220 230 240
CIGPDGDMHG VIPGECAVRL VKAGADIVGV NCHFDPLTCV KTVAMMKAAV EKAGLKAHYM
250 260 270 280 290 300
TQPLAYHTPD CSCQGFIDLP EFPFALEPRI LTRWEMQQYA REAYKAGIRY IGGCCGFEPY
310 320 330 340 350 360
HIRAVAEELS AERGFLPEAS QKHGLWGSGL EMHTKPWVRA RARRDYWEKL KPASGRPLCP
370 380 390
SMSTPDGWGV TRGHAALMQQ KEATTAEQLR PLFQQADAKH