Q32KP0

PR
Gene name
SMRP1 (CBE1)
Protein name
Spermatid-specific manchette-related protein 1
Names
Ciliated bronchial epithelial protein 1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:540767
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q32KP0

Entry ID Method Resolution Chain Position Source
8OTZ EM 360 A B0/B1/B2/B3/B4/B8/B9/CQ/CR/CS 1-304 PDB
AF-Q32KP0-F1 Predicted AlphaFoldDB

133 variants for Q32KP0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs440751772 2 F>L No EVA
rs478457731 6 R>* No EVA
rs462271165 10 T>P No EVA
rs442316645 11 P>H No EVA
rs476786505 12 I>L No EVA
rs439652029 21 A>G No EVA
rs456737904 21 A>P No EVA
rs456737904 21 A>T No EVA
rs454246905 23 T>A No EVA
rs454246905 23 T>P No EVA
rs433962430 24 S>Y No EVA
rs468613256 25 I>S No EVA
rs468613256 25 I>T No EVA
rs455590967 28 V>A No EVA
rs449883010 29 Y>* No EVA
rs469939518 29 Y>C No EVA
rs478090784 31 D>A No EVA
rs447338742 33 P>T No EVA
rs461581488 36 A>D No EVA
rs478370089 36 A>P No EVA
rs442262422 37 W>L No EVA
rs483324471 38 E>G No EVA
rs137545651 59 A>T No EVA
rs437619606 152 Y>* No EVA
rs469673155 153 P>R No EVA
rs481698194 163 E>G No EVA
rs467831242 164 R>P No EVA
rs450905590 165 E>Q No EVA
rs458798034 166 V>G No EVA
rs481975700 166 V>I No EVA
rs481975700 166 V>L No EVA
rs477092315 167 V>E No EVA
rs477092315 167 V>G No EVA
rs439428332 167 V>L No EVA
rs460482516 168 V>A No EVA
rs460482516 168 V>G No EVA
rs474867395 169 N>K No EVA
rs444149306 170 M>R No EVA
rs460963171 170 M>V No EVA
rs475371328 171 L>R No EVA
rs431984844 172 N>D No EVA
rs473680879 172 N>I No EVA
rs473680879 172 N>T No EVA
rs453635220 173 S>P No EVA
rs436538699 173 S>W No EVA
rs450869047 174 L>R No EVA
rs465331894 175 S>* No EVA
rs437272352 175 S>P No EVA
rs445175916 177 N>S No EVA
rs445175916 177 N>T No EVA
rs460393200 181 P>A No EVA
rs446743731 181 P>L No EVA
rs461167193 182 Q>* No EVA
rs475485839 182 Q>H No EVA
rs461167193 182 Q>K No EVA
rs444112505 182 Q>P No EVA
rs473041852 183 I>M No EVA
rs438416071 183 I>T No EVA
rs458661764 183 I>V No EVA
rs453490109 184 T>A No EVA
rs453490109 184 T>P No EVA
rs437384735 186 R>P No EVA
rs457357753 186 R>S No EVA
rs445341577 187 C>G No EVA
rs466187327 187 C>W No EVA
rs434738814 187 C>Y No EVA
rs446678909 188 G>A No EVA
rs450700118 189 C>F No EVA
rs461282227 189 C>G No EVA
rs461282227 189 C>R No EVA
rs482066176 189 C>W No EVA
rs438485738 190 V>G No EVA
rs458623063 190 V>L No EVA
rs459362205 191 D>A No EVA
rs479423474 191 D>Y No EVA
rs442425575 193 L>R No EVA
rs457523023 194 P>R No EVA
rs471818209 195 G>A No EVA
rs471818209 195 G>V No EVA
rs466090319 197 L>P No EVA
rs435611590 198 P>A No EVA
rs450863654 199 F>C No EVA
rs481966087 200 Q>R No EVA
rs444856176 201 G>E No EVA
rs465182899 201 G>R No EVA
rs459406288 202 Y>* No EVA
rs479541692 202 Y>C No EVA
rs479541692 202 Y>F No EVA
rs442402733 203 E>A No EVA
rs442402733 203 E>G No EVA
rs480058994 204 S>G No EVA
rs443901052 204 S>R No EVA
rs480058994 204 S>R No EVA
rs463849113 204 S>T No EVA
rs451897621 205 A>D No EVA
rs451897621 205 A>G No EVA
rs471779765 205 A>P No EVA
rs471779765 205 A>S No EVA
rs472714074 206 C>G No EVA
rs455805469 206 C>S No EVA
rs435570097 207 S>A No EVA
rs435570097 207 S>P No EVA
rs470190848 207 S>W No EVA
rs437108165 208 G>A No EVA
rs457196586 208 G>C No EVA
rs437108165 208 G>V No EVA
rs445004992 214 R>G No EVA
rs465868574 216 M>I No EVA
rs434623986 216 M>L No EVA
rs448892301 221 S>P No EVA
rs478296420 227 E>D No EVA
rs450262553 227 E>G No EVA
rs458407296 229 R>L No EVA
rs441400389 230 L>Q No EVA
rs441400389 230 L>R No EVA
rs472820328 231 R>G No EVA
rs442161471 232 P>A No EVA
rs476565751 232 P>L No EVA
rs456511967 233 L>F No EVA
rs433181674 234 C>S No EVA
rs471688950 235 T>P No EVA
rs465928258 236 E>G No EVA
rs210852367 236 E>K No EVA
rs469743636 238 P>R No EVA
rs449571974 239 T>P No EVA
rs458440935 240 V>E No EVA
rs479212815 241 R>G No EVA
rs462337788 241 R>T No EVA
rs460995605 274 S>R No EVA
rs444153300 279 T>P No EVA
rs438408736 283 Q>E No EVA
rs473720999 283 Q>P No EVA
rs453588759 301 Y>N No EVA

No associated diseases with Q32KP0

No regional properties for Q32KP0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q32KP0

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Nucleus
  • Cytoplasm
  • Mitochondrion
  • Cell projection, cilium, flagellum
  • During spermatid elongation (step 10), localizes along the length of the manchette and later during the elongation process only at the distal ends of spermatid manchette (step 12)
  • In late elongated spermatids (step 16), in the final steps of spermiogenesis, localization is restricted to the midpiece of the flagellum
  • Localizes at the contractile ring in dividing cells (By similarity)
  • Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
manchette A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

1 GO annotations of molecular function

Name Definition
alpha-tubulin binding Binding to the microtubule constituent protein alpha-tubulin.

2 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFLFSRKTKT PISTYSDSYR APTSIKEVYK DPPLWAWEAN KFVTPGLTHT AQRHVDPDAL
70 80 90 100 110 120
QKMLKCAVQD YSYKGSIPSH PYFPEKYWLC PEEADRCNPN YLCGNPNYLC SNQYNTWRMG
130 140 150 160 170 180
PYNCWNKCTT YLPRLPKEAG METVVRGMPL VYPPKPERLN AYEREVVVNM LNSLSRNQPL
190 200 210 220 230 240
PQITPRCGCV DPLPGRLPFQ GYESACSGRH YCLRGMDYCV SGPPCTERRL RPLCTELPTV
250 260 270 280 290 300
RSVSPCEHRS GMQCAVITPQ PSYYPCPNLR WDTSHFKKTG GSQRNNYVVH PEFVSETYPD
YHCW