Q31LT0

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans R2)
KEGG Pathway
syf:Synpcc7942_1959
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q31LT0

Entry ID Method Resolution Chain Position Source
AF-Q31LT0-F1 Predicted AlphaFoldDB

No variants for Q31LT0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q31LT0

No associated diseases with Q31LT0

6 regional properties for Q31LT0

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 97 - 485 IPR002314
domain Anticodon-binding 503 - 593 IPR004154
domain Aminoacyl-tRNA synthetase, class II 33 - 495 IPR006195
domain YbaK/aminoacyl-tRNA synthetase-associated domain 259 - 402 IPR007214
domain Prokaryote proline-tRNA ligase core domain 17 - 218 IPR033730
domain Proline--tRNA ligase, anticodon binding domain 500 - 592 IPR044140

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRLSQMLFVT LREDPAEAEI PSHKLLLRAG YIRRIASGIY AYLPLMWRVL RKVSQIVREE
70 80 90 100 110 120
MDATGAQETL LPQLQPAELW QESGRWETYT KAEGIMFSLD DRQQRQLGLG PTHEEVITAV
130 140 150 160 170 180
ARDLIRSYRQ LPQNLYQIQT KFRDEIRPRF GLMRGREFIM KDAYSFHADE ESLRQTYAAM
190 200 210 220 230 240
DQAYRNIFRR CGLQFRAVEA DSGAIGGSAS QEFMILADAG EDEILYTEDG RYAANVEKAV
250 260 270 280 290 300
SLPAEAIASA FTTFEKRETP GTDTIASLCE FLKADPTQVV KQVLYQAVFD NGKLLPILIS
310 320 330 340 350 360
IRGDQSVNEI KLTNELTRRA ADYGAKTVIA LTVPDAEALK KWTAAPLPLG YLGPDLADSA
370 380 390 400 410 420
IAVNESIIPK FLRLVDPTAA ELQNFVTGAN EVNFHVVGAN WETNFPKPAV VDLRTALVGD
430 440 450 460 470 480
RAQHDSSQVL ASARGIEAGH IFQLGLKYSQ AMGATFTTEN GTEEPLWMGC YGIGVSRVAQ
490 500 510 520 530 540
AAVEQSYDKD GIIWPVAIAP YQAVVVIPNI TDTEQVAAAE KIYADLTAAG IETLLDDRDE
550 560 570 580 590
RAGVKFKDAD LIGIPYRIVT GRSLKEGKVE VVQRASKESS VIAVGSVVET VQDWIAAAIV