Q31GU1

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) (Thiomicrospira crunogena)
KEGG Pathway
tcx:Tcr_1037
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

516-599 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q31GU1

Entry ID Method Resolution Chain Position Source
AF-Q31GU1-F1 Predicted AlphaFoldDB

No variants for Q31GU1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q31GU1

No associated diseases with Q31GU1

7 regional properties for Q31GU1

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 14 - 25 IPR001412
domain tRNA-binding domain 579 - 680 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 542 - 680 IPR004495
domain Methionyl/Leucyl tRNA synthetase 7 - 394 IPR015413
domain Methioninyl-tRNA synthetase core domain 6 - 369 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 382 - 393 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 372 - 517 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNTRKILIT SALPYANGPI HLGHLVEYIQ TDIWARFQKM RGHECYYVCA DDAHGTPIML
70 80 90 100 110 120
RAQAEGIDPE DLIARISEEH QTDFAGFNIN FDFYHSTNSP ENKHFASYIY TQLKEQNHIS
130 140 150 160 170 180
RKTIKQFYDP EKKMFLPDRF IKGTCPKCKT DDQYGDNCEA CGATYSPTDL LNPKSAVSGA
190 200 210 220 230 240
TPIEKETDHL FFELSHFEDM LKEWTHQGHL QTQIANKLDE WFESGLRAWD ISRDAPYFGF
250 260 270 280 290 300
EIPGEKDKFF YVWLDAPVGY MASFKALCDK TGLDFDEFWK ADSTTELYHF IGKDIIYFHA
310 320 330 340 350 360
LFWPAMLSGA GFRTPNAIFS HGFLTVDGQK MSKSRGTFIM AKTYLDHLNP EYLRYYFAAK
370 380 390 400 410 420
LNSRIDDIDL SLEDFAQRVN SDLVGKVVNI ASRCAGFVSK KFDGKLSQAW SDSASTLYQS
430 440 450 460 470 480
FIDKSETIAN LYEQREYAQA MREIMALADK ANEYIDETAP WVLAKQEGKE AELYESVSLG
490 500 510 520 530 540
INLFRVLITY LAPVIPTTAE KAQAFLQVDT LNWTDINTPL KDHEITKFKA LMTRVEIESI
550 560 570 580 590 600
EKMTDASKQD MKKMPPMKPE IKEEASNLDP IADEITFDDF AKVDFRIAKI VNAEQVPEAD
610 620 630 640 650 660
KLIKLTLDIG VGERQVFAGI KSAYKPEDLV GKLTVMVANL KPRKMRFGLS EGMVLAAGPG
670
GKDLFLLNPD DGAQPGMRVK