Q31F19

PR
Gene name
pheT
Protein name
Phenylalanine--tRNA ligase beta subunit
Names
Phenylalanyl-tRNA synthetase beta subunit, PheRS
Species
Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) (Thiomicrospira crunogena)
KEGG Pathway
tcx:Tcr_1662
EC number
6.1.1.20: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

155-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q31F19

Entry ID Method Resolution Chain Position Source
AF-Q31F19-F1 Predicted AlphaFoldDB

No variants for Q31F19

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q31F19

No associated diseases with Q31F19

6 regional properties for Q31F19

Type Name Position InterPro Accession
domain tRNA-binding domain 39 - 149 IPR002547
domain Ferrodoxin-fold anticodon-binding domain 700 - 793 IPR005121
domain B3/B4 tRNA-binding domain 214 - 387 IPR005146
domain tRNA synthetase, B5-domain 403 - 478 IPR005147
domain Phenylalanly tRNA synthetase, tRNA-binding-domain 45 - 148 IPR033714
domain Phenylalanyl tRNA synthetase beta chain, core domain 476 - 688 IPR041616

Functions

Description
EC Number 6.1.1.20 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVSESWLRE WVNPEWDTNT LAEELSLAGL EVDGIEPVAP AFTNVVVAKV ISVEKHPDAD
70 80 90 100 110 120
KLNVTQVDIG ADEPVQIVCG AKNVVAGMKA CCATVGAVLP GDFKIKKAKL RGVPSNGMLC
130 140 150 160 170 180
GANELGLPDD GVDGLHVLPA DAPVGTDLRE YLDLDDQVID VDLTPNRADC LSIAGVARDV
190 200 210 220 230 240
AAIGNVPFKQ PFDNVTVDKS GDCSQSVNVV DAHGCPKYLG CLVDGYDTTA ETPSWMKQRI
250 260 270 280 290 300
ERAGLSPKNL TVDITNYVML ELGQPMHAFD ADKLQGDIQV RMAHPNEKLM TLDEKELTLK
310 320 330 340 350 360
ADTLVIADDN GPVALAGIMG GLNSSVSDTT TRLFFECAHF APLSIIGKAR QYGLHTDSSH
370 380 390 400 410 420
RFERGVDAFL PEKALERALQ LFTEIAGGRV SNLVAVINEL NLHQPKAIQL RPERIVKLLG
430 440 450 460 470 480
VEIADNDVEA IFKRLNFKVE QNASGWALTA PSYRFDMEIE ADLIEEVGRV FGYNNLPETE
490 500 510 520 530 540
VQAPMRLPTL PESEQELYLV RKALVNRGFH EVVTYSFVEE TLQQKMMPSI PYLCLQNPIS
550 560 570 580 590 600
DDMKAMRTTL FPGLLQTISY NQKRQQNRIR IFESGLVFTR YNEETQQTPV IGGAIVGDLN
610 620 630 640 650 660
PANWSGENRP VDFYDLKGDV ETLLAMSHVQ DKVRFEPTEF AIFHPGQSAA LILNGQTVGL
670 680 690 700 710 720
MGQLHPGLVK SAGVSGKVYL FQMDLATIME TKVPAAKPIS KFPEVQRDLA FVVDAELPVQ
730 740 750 760 770 780
KLLDAIDHVQ SDILKAVEIF DIYQGEGIEE TQKSIALTLK IQHQDRTLQD EEVDQLIEQV
790
ILKAKEQVNA ELR