Q30Y29
Gene name |
hemC |
Protein name |
Porphobilinogen deaminase |
Names |
PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase |
Species |
Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) (Desulfovibrio alaskensis) |
KEGG Pathway |
dde:Dde_2621 |
EC number |
2.5.1.61: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q30Y29
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q30Y29-F1 | Predicted | AlphaFoldDB |
No variants for Q30Y29
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q30Y29 | |||||
No associated diseases with Q30Y29
1 regional properties for Q30Y29
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Uroporphyrinogen decarboxylase (URO-D) | 2 - 333 | IPR000257 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.61 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| hydroxymethylbilane synthase activity | Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-pyrromethane cofactor linkage | The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine. |
| protoporphyrinogen IX biosynthetic process | The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKKIVIATRG | SKLALWQAEH | IKERIMQQYP | DSFEVELLVL | KTKGDIILDV | PLAKVGGKGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FVKEIEEALL | DGRADIAVHS | MKDVPMELPQ | GLTLGAIPER | EVPTDSLLSA | RYDGLDALPQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GAVVGTSSLR | RQSQILAMRP | DLEVKWLRGN | VQTRIRKLMD | GEYDAIIMAT | SGLKRLGETA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PFHSELGPPL | FMPAVGQGAL | GLEYRSDRQD | LAEMLAFLDH | RPSRICVEAE | RGFLFGLQGG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CQVPIAGYAV | MTGDNSFELT | GLVAELDGTA | VIRRTAAGTE | ADARDTGLTL | AAQVKAAGAD |
| 310 | |||||
| AILQRVYENG | HASPQA |