Q30PA9

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
KEGG Pathway
tdn:Suden_1898
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q30PA9

Entry ID Method Resolution Chain Position Source
AF-Q30PA9-F1 Predicted AlphaFoldDB

No variants for Q30PA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q30PA9

No associated diseases with Q30PA9

4 regional properties for Q30PA9

Type Name Position InterPro Accession
domain DHHA1 domain 753 - 891 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 673 - 716 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 9 - 576 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 5 - 729 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDIREEFLRF FESKNHDRVE SAPLVPDDAT LLFNNAGMVP FKSIFTGEVP SPANPRAVSC
70 80 90 100 110 120
QTCIRAGGKH NDLENVGYTA RHHTFFEMLG NFSFGNYFKE EAIDYAWEFI TGVLKFPKEK
130 140 150 160 170 180
LWVTVHESDD EAEALWLRHV SIDRIMRLGD KDNFWQMGDT GPCGPCSEIF FDQGAEKFSG
190 200 210 220 230 240
PEDYMGGDGD RFLEIWNLVF MQYERSSDGT LTSLPKPSID TGMGLERVVA ISEGVSSNYS
250 260 270 280 290 300
SSLFMPIIKK VETLIEKEYV YATGASYRVI ADHIRTSLFL LAQGVNFSNE GRGYVLRRIL
310 320 330 340 350 360
RRAVRHGYLL GFSEPFMFKL VDTVVEIMGG EYDYLAQKSH SVKEQIELEE ARFFKTIASG
370 380 390 400 410 420
IELFNAELHN TKDIFSGSVA FKLYDTFGFP LDLTEDMLRE KNLKLDSAKF EELMQEQRSR
430 440 450 460 470 480
AKAAWKGSGD EAVHGDFKEL LEKFSENSFV GYESTKQKSR VLALLDESYH HADKLSAGVN
490 500 510 520 530 540
GWVFLDTTPF YAQSGGQCGD IGELNGFAKV LDTKKFFGLN LSQISTEKEL KVGDEVEAVV
550 560 570 580 590 600
DISRGEITKH HSATHLLHAV LFDVLGDHIS QAGSLVEASR LRFDFSHPKA ISNEELAEIE
610 620 630 640 650 660
RRVNYEIMRG IRANTEVMSI DEAKKSGAKA QFGEKYGDEV RVVSFGDASI EFCGGVHVEN
670 680 690 700 710 720
SANIGSFIIT KESGVSAGVR RIEAVCGNAA FNYFSEQREL LREVEHEVKN LDILAGVARL
730 740 750 760 770 780
KSNIVELKKE LHDAESCIKT DIKIQSINGI SVVVDELTSG DIKEKIDELK NQHESLCAIL
790 800 810 820 830 840
FQVKDDKVMM AAGVKGSDAK AGDWIKHIAP LLGGGGGGRA DFAQAGGKDI SKLSEAKIEA
LRYITEVIS