Q2YRB4

PR
Gene name
pdhS (BAB1_1621)
Protein name
Cell-division control histidine kinase PdhS
Names
Species
Brucella abortus (strain 2308)
KEGG Pathway
bmf:BAB1_1621
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

483-552 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2YRB4

Entry ID Method Resolution Chain Position Source
AF-Q2YRB4-F1 Predicted AlphaFoldDB

No variants for Q2YRB4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2YRB4

No associated diseases with Q2YRB4

6 regional properties for Q2YRB4

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 4 - 78 IPR000089-1
domain Biotin/lipoyl attachment 122 - 196 IPR000089-2
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 326 - 552 IPR001078
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 28 - 57 IPR003016-1
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 146 - 175 IPR003016-2
domain Peripheral subunit-binding domain 250 - 287 IPR004167

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cytoplasm
  • Localizes at the old pole of dividing cells
  • Colocalizes with DivK (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.

3 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGSYPFIDI AALDSVREGF ARGDAQLVLA HDLSTVLWVN GPGAKLFGYN RVEDLIEGQL
70 80 90 100 110 120
DLPVATRRQI AAFSSENTSA PSAVAVRLGG GLRSELTHLH VSNIKLPDGV AALLVATQMP
130 140 150 160 170 180
DNSAEAAISG LGDDSTHIAL VDAVGKVVAA SPRFALLDIS ASTLEDLIVE AGDATDRIVK
190 200 210 220 230 240
RRIRTGSHSV PGAIARLTDT PALHLLCIVG DAPAQFQTAA EAVPLPDNAE AVLEEILPEQ
250 260 270 280 290 300
GDAPAQQAQK THAEQPRPKT FAFDHDAPPA RFIWKVGPDG TFSEISPNLA AVVGPNSADI
310 320 330 340 350 360
VGRRFSDVAN VFGFDTDGSI AALLLERDTW SGKRLLWPVE GTRLRVPVEL AALPVYSRDR
370 380 390 400 410 420
EFLGFRGFGI VRPAEAEADP EEIGLALAGG IPQNRKPRKE PAETARMVGE DDVLALSEEV
430 440 450 460 470 480
ANDDQPAAVL PKPPLDITPT PGRRDSDKVI SLLNSCAQEK VAADQAKFLK EKERATRPEG
490 500 510 520 530 540
GLTKTERNAF REIAERLRKQ GLANTRAESE TPVSETSSIE PVEPTPPVKT RSEPIQPDET
550 560 570 580 590 600
ALLANLPVPV IIHSGDAIHY VNQALLDITG YESLDDIRSA GGVDVLFNSE SDDGETRQSM
610 620 630 640 650 660
LLRHADGSEE PVDAHLNAIA WRGGRALMLS LMPVTAADLP APAELPAAND EEKQALEAHV
670 680 690 700 710 720
EELKTILDTA TDGVVLIDPE GRIRSMNHSA SALFGYERDE AEGKFFSMLF AIESQRAAMD
730 740 750 760 770 780
YLHGLSGNGV LSVLNDGREV IGREAKGGFI PLFMTIGKLP HTRGFCAVLR DITQWKRTEE
790 800 810 820 830 840
ELTNARKEAE RASNQKTEFL ARISHEIRTP LNAIIGFSEL MADEKFGPIG NDRYRDYLRD
850 860 870 880 890 900
INRSGNHVLA LVNDLLDISK IEAGALDMQF EAVSLNDAIG EAIALMQPQA NRERVIIRSS
910 920 930 940 950 960
FQSNLPDIVA DSRSIKQVAL NLLSNAVRFT APGGQVIVST SYELNGDVVM RVRDTGIGMS
970 980 990 1000 1010 1020
KSEVEQALKP FRQINALERR KAESAKDWRN EGTGLGLPLT KAMVEANRAQ FAIDSNPGQG
1030
TVVEIVFPPT RVLAD