Q2YQ03
Gene name |
folE |
Protein name |
GTP cyclohydrolase 1 |
Names |
GTP cyclohydrolase I, GTP-CH-I |
Species |
Brucella abortus (strain 2308) |
KEGG Pathway |
bmf:BAB1_1097 |
EC number |
3.5.4.16: In cyclic amidines |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2YQ03
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2YQ03-F1 | Predicted | AlphaFoldDB |
No variants for Q2YQ03
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2YQ03 | |||||
No associated diseases with Q2YQ03
1 regional properties for Q2YQ03
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Riboflavin kinase domain, bacterial/eukaryotic | 18 - 172 | IPR015865 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.5.4.16 | In cyclic amidines |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTP cyclohydrolase I activity | Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| 7,8-dihydroneopterin 3'-triphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate. |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| tetrahydrofolate biosynthetic process | The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDARILQDND | DTSLPVNQAS | VTRIHKKPGK | AEAEAAVRTL | LLWAGEDPDR | EGLLETPKRV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AKAYQELFGG | YSESPEEVLG | TTFEEVAGYD | DMVLVKDISF | FSHCEHHMVP | IIGKAHVAYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PEGRVVGLSK | IARVVDIFAR | RLQTQESITA | QIADSIQRIL | KPRGVAVMIE | AEHMCMAMRS |
| 190 | 200 | 210 | |||
| IRKQGSSTIT | TTFTGDFKEK | ADQQVRFMTL | IRT |