Q2YD40

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
KEGG Pathway
nmu:Nmul_A0022
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2YD40

Entry ID Method Resolution Chain Position Source
AF-Q2YD40-F1 Predicted AlphaFoldDB

No variants for Q2YD40

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2YD40

No associated diseases with Q2YD40

4 regional properties for Q2YD40

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 874 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 656 - 699 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 557 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 712 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSSEVRQKF LEFFETHGHT IVPSSPLVPG NDPTLLFTNA GMVQFKDVFL GQDKRPYVRA
70 80 90 100 110 120
ASAQRCVRAG GKHNDLENVG YTARHHTFFE MLGNFSFGDY FKRNAIRFAW EFLTDILKIP
130 140 150 160 170 180
RERLWITVYA EDDEAADIWL NEVGIDSSRF TRIATQDNFW QMGDTGPCGP CSEIFYDHGP
190 200 210 220 230 240
EIPGGPPGTP NADGDRYVEI WNLVFMQYNR DSAGTLHPLP RPSVDTGMGL ERISAVMQQV
250 260 270 280 290 300
HSNYEIDLFQ QLIKAAARAT NTTDLSSSSL NVIADHIRAC SFLIADGVIP GNEGRGYVLR
310 320 330 340 350 360
RIIRRAIRHG YKLGQKQPFF HQLVEDLASV MGQAYPELME AKTRVSAVLK QEEERFAETL
370 380 390 400 410 420
ENGMQVLEAA LRRGDRMLDG ETLFRLYDTF GFPLDLTADI ARERGIAIDE AGFDQAMEQQ
430 440 450 460 470 480
RERARTTSKF IMQEAIAYSG PSTTFHGYES LRQEGQVLAI YKEGSRVEFI EAGDEAVIVL
490 500 510 520 530 540
DKTPFYAESG GQVGDSGELL AANGTFAVAD TQKIQADVFG HKGLLRSGRL ATGDAVLAEV
550 560 570 580 590 600
DRAARARTER NHSVTHLMHK ALREVLGHHV QQKGSLVDAN KTRFDFAHNQ PVTDAEIRKV
610 620 630 640 650 660
EMLVNAEILA NAATEARMMA IEDAKKSGAM MLFGEKYSDE VRVLDIGTSR ELCGGTHVKR
670 680 690 700 710 720
TGDIGLFKIV AESGVAAGVR RVEAVTGERA LTYIQEQELQ LQRVAAAVKA QPQDAAARIT
730 740 750 760 770 780
QILDNVKHLE RELGRMKSKL ASSQGDDFAD RVREIKGVKV LAVCLEEADP KTLREAVDKF
790 800 810 820 830 840
KNKFKSCVTV LAAVEDGKVK LIAGVTSDLT ARLKAGDLVN FVAQQVGGKG GGRADLAQAG
850 860
GTVPDSLPAA LESVASWVEQ HL