Q2Y6L9

PR
Gene name
mltF
Protein name
Membrane-bound lytic murein transglycosylase F
Names
Murein lyase F
Species
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
KEGG Pathway
nmu:Nmul_A2311
EC number
4.2.2.n1: Acting on polysaccharides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

435-478 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2Y6L9

Entry ID Method Resolution Chain Position Source
AF-Q2Y6L9-F1 Predicted AlphaFoldDB

No variants for Q2Y6L9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2Y6L9

No associated diseases with Q2Y6L9

3 regional properties for Q2Y6L9

Type Name Position InterPro Accession
active_site Prokaryotic transglycosylase, active site 312 - 340 IPR000189
domain Solute-binding protein family 3/N-terminal domain of MltF 46 - 269 IPR001638
domain Transglycosylase SLT domain 1 296 - 397 IPR008258

Functions

Description
EC Number 4.2.2.n1 Acting on polysaccharides
Subcellular Localization
  • Cell outer membrane; Peripheral membrane protein
  • Attached to the inner leaflet of the outer membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cell outer membrane A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

2 GO annotations of molecular function

Name Definition
carbon-oxygen lyase activity, acting on polysaccharides Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide.
lytic transglycosylase activity Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues.

3 GO annotations of biological process

Name Definition
cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
peptidoglycan metabolic process The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFPDSSYLFS MRSLSRFLIA IFGCGALLAS CDSFERSVLP FDKTDELVVI TVNSPDTYYE
70 80 90 100 110 120
NAEGSYAGLD YDLATEFAKE LGMKVRFKTV PRLDKAWSLL EKHKGHFAAG MNISAKHSRH
130 140 150 160 170 180
VAFGPIYQLV QPQLAYNTDY NKPKNLHQLG GRTIRIAKGV THAEQLNKAK HEVPELKWKE
190 200 210 220 230 240
MDLTPDELLA RLAEGKVDYV VADSTQINLA KNFYPNLNAA FNLGDSVGRA WAFSPFAEQA
250 260 270 280 290 300
LLEATQKFFT RIQQDGTLTR LLDRYYGHIE RLHHTDVNGI LAKRRTILPE LREHFYEAEE
310 320 330 340 350 360
LSGIDWRLIA ALAYQESHWD ALATSPSNVR GIMMLTEITA DRMKVTDRLD ARQSILAGAR
370 380 390 400 410 420
YFALLKDKLP TRIKEPDRTW MALAAYNQGP SHLEDARILA QKMGLSPDAW VDLKKTLPLL
430 440 450 460 470
SQSEHFRTLR HGFARGGQAV VLAESVRIYY EILQKYEPPY SWGFPIVARK EDDSWQEF