Q2Y2L8

PR
Gene name
L
Protein name
RNA-directed RNA polymerase L
Names
Protein L, Large structural protein, Replicase, Transcriptase
Species
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

579-649 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q2Y2L8

Entry ID Method Resolution Chain Position Source

No variants for Q2Y2L8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2Y2L8

No associated diseases with Q2Y2L8

4 regional properties for Q2Y2L8

Type Name Position InterPro Accession
domain Mononegavirales RNA-directed RNA polymerase catalytic domain 15 - 1105 IPR014023
domain Mononegavirus L protein 2-O-ribose methyltransferase 1662 - 1852 IPR025786
domain Mononegavirales mRNA-capping domain V 1127 - 1333 IPR026890
domain RNA-directed RNA polymerase L, C-terminal 1210 - 2002 IPR039736

Functions

Description
EC Number
Subcellular Localization
  • Virion
  • Host cytoplasm
  • Localizes in cytoplasmic inclusion bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
metal ion binding Binding to a metal ion.
mRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDPLNEGVVN VYLTDSYLKG VISFSETNAI GSCLLGKHYL KKDNTSKVAI ESPVVEHIRL
70 80 90 100 110 120
RNAFQTRIKE KNLRVVEPVN MQSEVMRNSY TCELNLLKQL ITRSKDISSL KLDMICDWLQ
130 140 150 160 170 180
LKSTSENPSV LKFVDVRCIP DWVSTWFSSW YNLNKLILEF RREEVACTGS IICKTIGSIM
190 200 210 220 230 240
FIISSFGCVI KSNKSKRISF MTYNQVLTWK DVMLSRFNAN LCVWISNSLN KNQEGLGLRS
250 260 270 280 290 300
NLQGALVNKL YEIVDSMLSV CSNEGFTLVK EFEGFIMSEI LKITEHAQFS TRFRNTLLNG
310 320 330 340 350 360
LVDQLAKMRG LNRKRVSGTV LEGNQYPMYE TTLATLGGAL KTIRLLVNKN LDNAAELYYI
370 380 390 400 410 420
FRIFGHPMVE EREAMDAVRL NNEITKILKL ESLTELRGAF ILRIIKGFVD TNKRWPKIKN
430 440 450 460 470 480
LKVLSRRWIM YFKAKSYPSQ LELSSQDFLE LAGVQFEQEF AIPERTNLEM VLNDKAISPP
490 500 510 520 530 540
KNLIWSVFPK NYLPTNIRER FTEEMFNSSE KLKTRRVLEY YLKDNKFDQN DLKKYVVRQE
550 560 570 580 590 600
YLGDKEHVVS LTGKERELSV GRMFAMQPGK QRQVQILAEK LLADNIVPFF PETLTKYGDL
610 620 630 640 650 660
ELQRIMEIKS ELSSVKSRRN DSYNNYIARA SIVTDLSKFN QAFRYETSSV CADVVDELHG
670 680 690 700 710 720
TQSLFCWLHL TVPLTTMICT YRHAPPETEG VYDIDKIKEQ SGLYRFHMGG IEGWCQKLWT
730 740 750 760 770 780
MEAVSLLDVV SVKNRVQLTS LLNGDNQSID VSKPVRLSQG VDEVKADYSL AVKMLKEIRN
790 800 810 820 830 840
AYKDIGHKLK EGETYISRDL QFMSKVIQSE GVMHPSPIKK ILRVGPWINT ILDDIKTSAE
850 860 870 880 890 900
SIGSLCQELE FRGESLLVSL ILRNFWLYEL WMHESKSHPL AGKQLYRQLS KTLAITQKFF
910 920 930 940 950 960
GITKETDVVN LWMNVPMQFG GGDPVVLYRS FYRRTPDFLT EAVSHMSVLL KVYGKAKEGS
970 980 990 1000 1010 1020
KKDFFKALLS VDKNKRATLT TLMRDPQAVG SERQARVTSE INRAAVTSVL SLSPNQLFCD
1030 1040 1050 1060 1070 1080
SAIHYSRNEE EVGLIAQNIT PVYPHGLRVL YESLPFHKAE KVVNMISGTK SITNLLQRTS
1090 1100 1110 1120 1130 1140
AINGEDIDRA VSMMLENLGL LSRILSVCQD DITLPTKANG DLICCQVSRT LRERSWDNME
1150 1160 1170 1180 1190 1200
IVGVTSPSIV TCMNIVYSSS SQLKGITIEK FSTDKTTRGQ RGPKSPWVGS STQEKKLVPV
1210 1220 1230 1240 1250 1260
YNRQILSKQQ KEQLEAIGKL RWVYKGTQGL RRLLDKICIG SLGISYKNVK PLLPRFMSVN
1270 1280 1290 1300 1310 1320
FLHRLSVSSR PMEFPASVPA YRTTNYHFDT SPVNQTLSER FGNEDINLVF QNAISCGISV
1330 1340 1350 1360 1370 1380
MSVVEQLTGR SPKQLVMIPQ LEEIDIMPPP VFLGKFDYKL VEKISSDQHI FSPDKLDLVT
1390 1400 1410 1420 1430 1440
LGKMLMPSTS GAKSDQFWNR KENFFHGNNL VESLSAALAC HWCGILTEQC NENNIFRREW
1450 1460 1470 1480 1490 1500
GDGFVTDHAF IDFKTFVGVF KTKLLCGWGS RGGDIKDRDM IDESIDKLIR VDNSFWRMFS
1510 1520 1530 1540 1550 1560
KVILEPKVRK RVMLFDVKIL SLVGYAGFKN WFIDHLRSSD LCEVPWVVNA DSEIVEVSAV
1570 1580 1590 1600 1610 1620
KIYLQLLRVS SPLRITVLNY SDMAHAITRL IRRKSMHDNV PSISRTLSPA ELAPVVEPTV
1630 1640 1650 1660 1670 1680
QMNLFPKITF ERLKNYETVS GSTRGKLTRN YMVMLPWQHI NRFNFVFSST GCKISVKACI
1690 1700 1710 1720 1730 1740
GRLIQDLNPT VFYFVGEGAG NWMARTACEY PNAKFVYRSL KDDLDHHFPL EFQRVLGNMN
1750 1760 1770 1780 1790 1800
RVIDGGEGLS MDTTDATQKT HWDLIHRICK DALLITLCDA EFKDRDDFFK MVTLWRKHVL
1810 1820 1830 1840 1850 1860
SCRICTTYGT DLYLFAKYHA KEQSIKLPYF VRSIATYVMQ GSKLSGSECY VLLTLGHHNN
1870 1880 1890 1900 1910 1920
LPCHGEVQSS KLKLAVCNDF SIPRKVEVKA VEANCKSLLS GLRTPINRAE LDRQKKMLTL
1930 1940 1950 1960 1970 1980
RSYHSSVATV GGSRVIESKW LSKKATTIIE WLEHILNSPK GELNYDFFEA LENTYPNMVK
1990 2000
LLDNLGSAEL KKLIKVTGYM LMSKK