Q2VUH7
Gene name |
Dixdc1 (Ccd1) |
Protein name |
Dixin |
Names |
Coiled-coil protein DIX1 , Coiled-coil-DIX1 , DIX domain-containing protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
rno:363062 |
EC number |
|
Protein Class |
|
Descriptions
(Annotation based on sequence homology with Q07960)
Rho GTPase-activating protein 1 (p50RhoGAP) comprises an N-terminal BCH domain and a C-terminal GAP domain separated by a proline-rich region. p50RhoGAP contains a non-canonical RhoA-binding motif in its BCH domain and is associated with GAP-mediated cell rounding. In the autoinhibited state, the GAP catalytic residue is being occluded and incapable of RhoA inactivation, and it only becomes accessible upon the release of autoinhibition of GAP from the BCH domain. The lipid binding to BCH domain may initiate the transition for the release of GAP domain from the inactive state to the active state of p50RhoGAP. This leads to the activation of the GAP domain of p50RhoGAP, resulting in the GAP-mediated GTPase inactivation of RhoA.
Autoinhibitory domains (AIDs)
Target domain |
650-659 (β3-β4 loop) |
Relief mechanism |
Partner binding, PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2VUH7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2VUH7-F1 | Predicted | AlphaFoldDB |
No variants for Q2VUH7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2VUH7 | |||||
No associated diseases with Q2VUH7
8 regional properties for Q2VUH7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 478 - 702 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1127 - 1361 | IPR003439-2 |
| domain | AAA+ ATPase domain | 506 - 679 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1153 - 1346 | IPR003593-2 |
| domain | ABC transporter type 1, transmembrane domain | 127 - 404 | IPR011527-1 |
| domain | ABC transporter type 1, transmembrane domain | 793 - 1089 | IPR011527-2 |
| conserved_site | ABC transporter-like, conserved site | 604 - 618 | IPR017871-1 |
| conserved_site | ABC transporter-like, conserved site | 1264 - 1278 | IPR017871-2 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon terminus | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| stress fiber | A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| frizzled binding | Binding to a frizzled (fz) receptor. |
| gamma-tubulin binding | Binding to the microtubule constituent protein gamma-tubulin. |
| mitogen-activated protein kinase kinase kinase binding | Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. |
| protein domain specific binding | Binding to a specific domain of a protein. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| canonical Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| cell proliferation in forebrain | The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. |
| cerebellar cortex development | The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. |
| cerebral cortex cell migration | The orderly movement of cells from one site to another in the cerebral cortex. |
| cerebral cortex radially oriented cell migration | The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. |
| forebrain ventricular zone progenitor cell division | The mitotic division of a basal progenitor giving rise to two neurons. |
| negative regulation of neuron differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. |
| positive regulation of axonogenesis | Any process that activates or increases the frequency, rate or extent of axonogenesis. |
| positive regulation of JNK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
| positive regulation of Wnt signaling pathway | Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| regulation of microtubule cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPLSELQDD | LTLDDTSQAL | NQLKLASIDE | KNWPSDEMPD | FPKSDDSKSS | SPEPVTHLKW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDPYYDIARH | QIVEVAGDDK | YGRKIIVFSA | CRMPPSHQLD | HSKLLGYLKH | TLDQYVESDY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLLYLHHGLT | SDNKPSLSWL | RDAYREFDRK | YKKNIKALYI | VHPTMFIKTL | LILFKPLISF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KFGRKIFYVN | YLSELSEHVK | LEQLGIPRQV | LKYDDFLKST | QKSPATAPKP | MPPRPPLPNQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QFGVSLQHLQ | EKSPGQDPIP | IVLRETVAYL | QAHALTTEGI | FRRSANTQVV | REVQQKYNMG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LPVDFDQYNE | LHLPAVILKT | FLRELPEPLL | TFDLYPHVVG | FLNIDESQRV | EVTQQVLQTL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEENYQVLHF | LTAFLVQISA | HCDQNKMTNT | NLAVVFGPNL | LWAKDAAITL | KAINPINTFT |
| 430 | |||||
| KFLLDHQGEL | FPSTDAQGV |