Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2UDB2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2UDB2-F1 | Predicted | AlphaFoldDB |
No variants for Q2UDB2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2UDB2 | |||||
No associated diseases with Q2UDB2
5 regional properties for Q2UDB2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 155 - 163 | IPR000629 |
| domain | Helicase, C-terminal | 235 - 387 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 28 - 192 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 23 - 225 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 4 - 32 | IPR014014 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAANYWASTQ | RRHWLFTKER | LADIRESFRE | RDKAAHSQFP | LPDQRLLNIY | FSQQLIKLGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RMSTRQQALA | TAQVYIKRFY | TKNEIRHTNP | YLVVTTAFYL | ACKMEECPQH | IRFVVAEARN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FWPEFIAPDV | SKLGECEFAL | ISEMNSQLIV | HHPYRTLSEL | QPELSLTSDE | VALAWSVIND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HYLTDLPLLY | PPHVIAVMAI | IVAVVFKPSQ | TSFHGTAAPL | AGAMRDGGMN | ILAALGDKNG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AGPPPRIQKL | VGWLAESEVD | IRAVIECTQE | LVSLYEIWEN | YSEKHCKELL | GRMVKSKNLD |
| K |