Q2TBM9
PR
Gene name |
SERAC1 |
Protein name |
Protein SERAC1 |
Names |
Serine active site-containing protein 1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:519860 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2TBM9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2TBM9-F1 | Predicted | AlphaFoldDB |
84 variants for Q2TBM9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs439825321 | 64 | Q>K | No | EVA | |
| rs452277159 | 94 | A>T | No | EVA | |
| rs443493036 | 118 | A>D | No | EVA | |
| rs457768935 | 119 | D>A | No | EVA | |
| rs476540614 | 119 | D>H | No | EVA | |
| rs478976137 | 121 | F>L | No | EVA | |
| rs460337196 | 134 | W>R | No | EVA | |
| rs441765729 | 135 | L>V | No | EVA | |
| rs474828994 | 137 | L>V | No | EVA | |
| rs444540617 | 140 | S>I | No | EVA | |
| rs456435139 | 140 | S>R | No | EVA | |
| rs470805600 | 140 | S>R | No | EVA | |
| rs452420633 | 142 | S>A | No | EVA | |
| rs467207451 | 143 | D>V | No | EVA | |
| rs436534165 | 146 | A>E | No | EVA | |
| rs455244383 | 146 | A>S | No | EVA | |
| rs449791751 | 148 | R>P | No | EVA | |
| rs445696214 | 151 | A>P | No | EVA | |
| rs478669421 | 152 | V>A | No | EVA | |
| rs478669421 | 152 | V>D | No | EVA | |
| rs460356440 | 154 | E>D | No | EVA | |
| rs441918146 | 155 | M>L | No | EVA | |
| rs481268411 | 155 | M>R | No | EVA | |
| rs441918146 | 155 | M>V | No | EVA | |
| rs462630890 | 156 | S>P | No | EVA | |
| rs444481284 | 158 | A>P | No | EVA | |
| rs444481284 | 158 | A>T | No | EVA | |
| rs452507553 | 162 | H>Q | No | EVA | |
| rs460005604 | 183 | R>* | No | EVA | |
| rs453896491 | 190 | R>L | No | EVA | |
| rs478450638 | 247 | G>C | No | EVA | |
| rs472877008 | 249 | L>F | No | EVA | |
| rs460905015 | 251 | C>G | No | EVA | |
| rs442327988 | 251 | C>W | No | EVA | |
| rs475212763 | 252 | F>C | No | EVA | |
| rs432317808 | 254 | G>R | No | EVA | |
| rs471583897 | 254 | G>V | No | EVA | |
| rs434581368 | 256 | G>E | No | EVA | |
| rs449409268 | 259 | Y>F | No | EVA | |
| rs458032955 | 261 | E>* | No | EVA | |
| rs437185858 | 261 | E>G | No | EVA | |
| rs470219074 | 262 | S>R | No | EVA | |
| rs445505405 | 264 | G>* | No | EVA | |
| rs445505405 | 264 | G>R | No | EVA | |
| rs478583017 | 265 | E>K | No | EVA | |
| rs460069197 | 267 | P>H | No | EVA | |
| rs447763231 | 268 | S>* | No | EVA | |
| rs480621179 | 269 | A>D | No | EVA | |
| rs460837486 | 271 | V>A | No | EVA | |
| rs460837486 | 271 | V>E | No | EVA | |
| rs463342707 | 275 | C>F | No | EVA | |
| rs475202262 | 275 | C>R | No | EVA | |
| rs438669230 | 276 | L>F | No | EVA | |
| rs471639350 | 280 | V>G | No | EVA | |
| rs441033956 | 325 | M>L | No | EVA | |
| rs382552957 | 353 | I>V | No | EVA | |
| rs446836942 | 357 | S>Y | No | EVA | |
| rs479814503 | 370 | T>N | No | EVA | |
| rs435520705 | 389 | S>R | No | EVA | |
| rs386018489 | 423 | V>I | No | EVA | |
| rs474031559 | 452 | E>D | No | EVA | |
| rs462216263 | 454 | D>A | No | EVA | |
| rs443744509 | 455 | T>P | No | EVA | |
| rs476604171 | 460 | W>* | No | EVA | |
| rs451644425 | 468 | R>M | No | EVA | |
| rs518293856 | 475 | S>G | No | EVA | |
| rs435167461 | 481 | K>T | No | EVA | |
| rs468195045 | 483 | R>G | No | EVA | |
| rs209114168 | 514 | R>K | No | EVA | |
| rs479429936 | 572 | D>G | No | EVA | |
| rs460986436 | 597 | S>R | No | EVA | |
| rs448800394 | 598 | M>L | No | EVA | |
| rs463658143 | 601 | L>P | No | EVA | |
| rs482144071 | 601 | L>V | No | EVA | |
| rs438577002 | 602 | H>P | No | EVA | |
| rs471634018 | 603 | V>G | No | EVA | |
| rs459834654 | 604 | V>G | No | EVA | |
| rs474323647 | 606 | L>R | No | EVA | |
| rs455691832 | 607 | D>G | No | EVA | |
| rs437183251 | 608 | S>A | No | EVA | |
| rs437183251 | 608 | S>P | No | EVA | |
| rs476665027 | 608 | S>W | No | EVA | |
| rs451928965 | 609 | A>G | No | EVA | |
| rs442200520 | 620 | D>G | No | EVA |
No associated diseases with Q2TBM9
No regional properties for Q2TBM9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q2TBM9 | |||
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| extracellular matrix | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondria-associated endoplasmic reticulum membrane | A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| extracellular matrix organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
| intracellular cholesterol transport | The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells. |
| phosphatidylglycerol acyl-chain remodeling | Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. |
| phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLAAYCVIC | CRRMGTSTPP | PKSSTYWRDI | RNIIKFTGSL | ILGGSLFITY | EVLALKKSLT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDTQVIEREK | MKSYIYVHTV | SLDKTENHGI | TYQARKELHK | AVRKVLATSA | RIFRGPFADT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FSTVDIEDHD | CAVWLLLRKS | RSDDRAARLQ | AVQEMSEARH | WHDYQYRIIA | QACDMRTLTG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LARSKDSDLR | FFLRPPPLPS | LKEDSSTEEE | LRHLLASLPQ | TDLDECIQCF | TALALSESSQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLAAQKGGLW | CFGGNGLPYA | ESFGEVPSAT | VEMFCLEALV | KHSEIPTHCD | KIEANGGLQL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LQRLYQLHKD | CPKVQRNIMR | ILGNMALNEH | LHSTIVRSGW | VSILAEAIKS | QHIMEASHAA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RTLANLDRET | VPDKYHDGVY | VLHPQYRTSQ | PIKADVLFIH | GLMGAAFKTW | RQQDNDQDLT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EKVSEDETKY | TTCWPKSWLA | RDCPALRIIS | VEYDTSLSDW | RARCPTERKS | IAFRSNELLR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLRAAGVGDR | PVVWVSHSMG | GLLVKKMLLE | ASKRPEMNTI | INNTRGIIFY | SVPHHGSHLA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EYSVNIRYLL | FPSLEVKELS | KDSPALKTLQ | DDFLEFAKDK | NFQVLSFVET | LPTYIGSMIK |
| 610 | 620 | 630 | 640 | 650 | |
| LHVVPLDSAD | LGLGDLIPVD | VNHLNICKPK | KKDAFLYQRT | LQFIRDALAK | DLEN |