AiPD: Autoinhibited Protein Database

Q2TAP0

Gene name	GOLGA7B (C10orf132, C10orf133)
Protein name	Golgin subfamily A member 7B
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:401647
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

106-167 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

106-167 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q2TAP0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q2TAP0-F1	Predicted				AlphaFoldDB

126 variants for Q2TAP0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1384166085 CA377991262	8	L>P		No	ClinGen gnomAD
rs746126130 CA5635795	10	E>D		No	ClinGen ExAC gnomAD
rs531579996 CA5635794	10	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs772148450 CA5635797	12	R>L		No	ClinGen ExAC TOPMed gnomAD
rs772148450 CA5635796	12	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA212714190 rs370419153	12	R>W		No	ClinGen ESP TOPMed gnomAD
CA5635799 rs768638204	13	R>*		No	ClinGen ExAC TOPMed gnomAD
rs761671560 CA5635801 COSM261119	13	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs769589632 CA5635802	15	A>T		No	ClinGen ExAC gnomAD
CA5635803 rs374417789	15	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5635804 rs143455176	16	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1467247466 CA377991308	17	L>P		No	ClinGen gnomAD
CA212714257 rs567531286	17	L>V		No	ClinGen Ensembl
rs765913755 CA5635805	18	A>V		No	ClinGen ExAC gnomAD
CA5635806 rs751126796	21	V>F		No	ClinGen ExAC
CA5635807 rs758951956	26	D>G		No	ClinGen ExAC
CA377991364 rs199703901	26	D>H		No	ClinGen TOPMed
rs199703901 CA212714283	26	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5635809 rs200719626	29	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1473072534 CA377991450	36	Q>E		No	ClinGen gnomAD
TCGA novel	36	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377991468 rs1564865623	37	T>N		No	ClinGen Ensembl
CA5635811 rs779454360	39	F>C		No	ClinGen ExAC gnomAD
rs757794979 CA5635810	39	F>L		No	ClinGen ExAC TOPMed gnomAD
CA212714328 rs1053715920	41	P>L		No	ClinGen TOPMed
TCGA novel	41	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757847652 CA5635813	41	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1327248459 CA377991523	42	E>G		No	ClinGen gnomAD
rs1393453223 CA377991516	42	E>K		No	ClinGen gnomAD
TCGA novel	42	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768728042 CA5635817	46	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5635816 rs768728042	46	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs747181097 CA5635815	46	R>W		No	ClinGen ExAC TOPMed gnomAD
rs372050656 CA5635833	49	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs368130428 CA5635832	49	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA377992270 rs1590163558	50	Q>R		No	ClinGen Ensembl
CA5635834 rs781280819	51	L>V		No	ClinGen ExAC
TCGA novel	54	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377992327 rs1230956728	54	E>Q		No	ClinGen TOPMed
rs1314113158 CA377992353	56	V>M		No	ClinGen TOPMed
rs748194897 CA5635835	58	T>N		No	ClinGen ExAC gnomAD
CA212716986 rs1038989582	61	G>E		No	ClinGen TOPMed
rs1466835263 CA377993203	61	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	63	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs377092921 CA5635841	64	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs771822768 CA377993291	66	A>P		No	ClinGen ExAC gnomAD
rs771822768 CA5635842	66	A>S		No	ClinGen ExAC gnomAD
rs760249871 CA5635844	69	I>T		No	ClinGen ExAC TOPMed gnomAD
CA377993377 rs1258830973	71	G>D		No	ClinGen TOPMed
CA212717009 rs1030482268	71	G>S		No	ClinGen TOPMed
rs765840144 CA5635845	72	S>I		No	ClinGen ExAC gnomAD
CA377993420 rs1183018218	74	Y>C		No	ClinGen TOPMed
rs932282510 CA212717014	74	Y>H		No	ClinGen Ensembl
rs1183018218 CA377993419	74	Y>S		No	ClinGen TOPMed
rs773598891 CA5635847	75	L>F		No	ClinGen ExAC gnomAD
rs773598891 CA5635846	75	L>I		No	ClinGen ExAC gnomAD
CA5635848 rs766675204	76	E>K		No	ClinGen ExAC TOPMed gnomAD
CA377993461 rs1325465104	77	G>C		No	ClinGen TOPMed gnomAD
CA377993458 rs1325465104	77	G>S		No	ClinGen TOPMed gnomAD
rs755233805 COSM1253388 CA5635850	82	A>T	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1007342675 COSM173875 CA212717048	83	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1267548316 CA377993622	86	F>L		No	ClinGen gnomAD
TCGA novel	87	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	92	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1323355778 CA377993741	93	T>N		No	ClinGen TOPMed
CA5635855 rs777839323	93	T>S		No	ClinGen ExAC gnomAD
rs759344235 CA212717094	94	H>D		No	ClinGen Ensembl
CA5635856 rs749193011	96	E>K		No	ClinGen ExAC TOPMed gnomAD
rs757195101 CA5635874	100	K>R		No	ClinGen ExAC gnomAD
CA5635875 rs778985189	104	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5635876 rs750311602 COSM258706	104	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs941612201 CA212717260	107	Q>R		No	ClinGen TOPMed gnomAD
CA377994047 rs1177081301	108	E>G		No	ClinGen gnomAD
rs779939304 CA5635878	108	E>Q		No	ClinGen ExAC gnomAD
rs1453615679 CA377994093	111	E>D		No	ClinGen TOPMed
CA377994120 rs1303405931	114	F>L		No	ClinGen TOPMed gnomAD
rs746683484 CA5635881	115	A>V		No	ClinGen ExAC
CA377994140 rs1417305151	116	P>T		No	ClinGen gnomAD
CA5635883 rs780606484	117	R>*		No	ClinGen ExAC gnomAD
TCGA novel	117	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA212717298 rs141259574	117	R>Q		No	ClinGen ESP
CA377994160 rs1172889732	118	G>A		No	ClinGen gnomAD
rs1347058184 CA377994166	119	L>F		No	ClinGen gnomAD
rs1352530107 CA377994196	122	T>K		No	ClinGen gnomAD
CA5635884 rs200808621	123	D>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	123	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377994220 rs1428701656	125	V>M		No	ClinGen TOPMed
CA377994231 rs1303319248	126	E>A		No	ClinGen gnomAD
CA212717321 rs750443345	127	R>C		No	ClinGen TOPMed gnomAD
rs375682387 CA5635886	127	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5635919 rs752404058	132	I>T		No	ClinGen ExAC TOPMed
CA5635920 rs755711919	134	I>F		No	ClinGen ExAC TOPMed gnomAD
rs755711919 CA377994384	134	I>L		No	ClinGen ExAC TOPMed gnomAD
rs748777328 CA5635922	136	I>V		No	ClinGen ExAC TOPMed gnomAD
CA377994415 rs375513503	137	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA377994419 rs1156816203	138	E>G		No	ClinGen gnomAD
rs901352162 CA212718266	138	E>K		No	ClinGen gnomAD
rs1461522376 CA377994430	139	D>E		No	ClinGen TOPMed gnomAD
rs780609461 CA5635924	139	D>N		No	ClinGen ExAC gnomAD
rs747412494 CA377994433	140	R>G		No	ClinGen ExAC TOPMed gnomAD
CA212718274 rs1010380728	140	R>Q		No	ClinGen TOPMed gnomAD
rs747412494 CA5635925	140	R>W		No	ClinGen ExAC TOPMed gnomAD
rs776814365 CA5635928	141	C>Y		No	ClinGen ExAC
rs1216116056 CA377994450	142	S>T		No	ClinGen TOPMed
rs770107830 CA5635930	144	G>D		No	ClinGen ExAC gnomAD
rs1280400545 CA5635936	149	G>S		No	ClinGen TOPMed
rs1332938134 CA377994516	150	S>G		No	ClinGen gnomAD
rs773473661 CA5635938	151	S>N		No	ClinGen ExAC gnomAD
CA377994543 rs1166496220	153	G>D		No	ClinGen gnomAD
CA5635940 rs766490550	153	G>S		No	ClinGen ExAC gnomAD
CA377994556 rs1564868055	155	G>S		No	ClinGen Ensembl
CA212718387 rs530051798	157	S>R		No	ClinGen 1000Genomes
CA5635942 rs759330644	159	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1327387471 CA377994600	160	G>E		No	ClinGen gnomAD
CA5635943 rs767364497	160	G>R		No	ClinGen ExAC gnomAD
rs767364497 CA377994599	160	G>W		No	ClinGen ExAC gnomAD
CA212718443 rs958327725	163	G>R		No	ClinGen gnomAD
CA377994635 rs373874556	164	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1458392408 CA377994633	164	A>P		No	ClinGen TOPMed
CA5635945 rs373874556	164	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs753416888 CA5635947	165	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1013968355 CA212718471	166	A>T		No	ClinGen TOPMed
rs756768647 CA377994658	167	R>L		No	ClinGen ExAC TOPMed gnomAD
rs756768647 CA377994657	167	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5635948 rs756768647	167	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1193888972 CA377994654	167	R>W		No	ClinGen gnomAD

No associated diseases with Q2TAP0

1 regional properties for Q2TAP0

Type	Name	Position	InterPro Accession
domain	Golgin subfamily A member 7/ERF4	21 - 133	IPR019383

Functions

		Description
EC Number
Subcellular Localization	Cell membrane Golgi apparatus membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
palmitoyltransferase complex	A protein complex with palmitoyltransferase activity.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
enzyme binding	Binding to an enzyme, a protein with catalytic activity.

2 GO annotations of biological process

Name	Definition
peptidyl-L-cysteine S-palmitoylation	The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine.
protein targeting to membrane	The process of directing proteins towards a membrane, usually using signals contained within the protein.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9D428	GOLGA7B	Golgin subfamily A member 7B	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MATEVHNLQE	LRRSASLATK	VFIQRDYSDG	TICQFQTKFP	PELDSRIERQ	LFEETVKTLN
70	80	90	100	110	120
GFYAEAEKIG	GSSYLEGCLA	CATAYFIFLC	METHYEKVLK	KISRYIQEQN	EKIFAPRGLL
130	140	150	160
LTDPVERGMR	VIEISIYEDR	CSSGSSSSGS	SSGSGSSSGG	GGGAGAR