Q2SKU2

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Hahella chejuensis (strain KCTC 2396)
KEGG Pathway
hch:HCH_01897
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

516-595 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2SKU2

Entry ID Method Resolution Chain Position Source
AF-Q2SKU2-F1 Predicted AlphaFoldDB

No variants for Q2SKU2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2SKU2

No associated diseases with Q2SKU2

7 regional properties for Q2SKU2

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 15 - 26 IPR001412
domain tRNA-binding domain 580 - 681 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 548 - 681 IPR004495
domain Methionyl/Leucyl tRNA synthetase 8 - 396 IPR015413
domain Methioninyl-tRNA synthetase core domain 7 - 363 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 384 - 395 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 374 - 506 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGEPRKILV TSALPYANGP IHLGHLLEYI QTDIWVRFQK LRGHQCTYVC ADDAHGTAIM
70 80 90 100 110 120
LKAEQMGITP EQLIDQVNAD HRRDFAEFLI EFDNYYSTHS EENRELSSYI YKACLDAGKI
130 140 150 160 170 180
ATRTITQAYD PEKNLFLADR FIKGTCPKCK AEDQYGDNCE VCSSTYTPAE LINPRSAISG
190 200 210 220 230 240
ATPIEKESTH FFFKLPDFQE FLQKWTRSGT LQPQIANKLA EWLDAGLQEW DISRDAPYFG
250 260 270 280 290 300
FEIPDQPGKF FYVWLDAPIG YMASFKNLCA RRADLDFDEY WKKDSTAELY HFIGKDIINF
310 320 330 340 350 360
HALFWPSMLS CADFRTPSAV YAHGFVTVDG AKMSKSRGTF IMARTYLEHL NPEYLRYYFA
370 380 390 400 410 420
AKLTSNVDDL DLNLQDFTLK VNADLVGKLV NIASRCAKFI TKAGGKLSPQ ISEPELIEQF
430 440 450 460 470 480
LSKSDFIAQA YEDREFGKAV REIMALADLA NKYIDEKAPW KLAKEEGKEQ EVLDVCSVGV
490 500 510 520 530 540
NLFRILITYL APVLPGVAAA SAEFLNAPIV WNRPLEPLTD HAVNEFKPMI SRVDPKAVDA
550 560 570 580 590 600
MVDASKDNMA QAPKDNGKAK KDKKEAKSEE EIAPTIKFDD FAKIDLRIAK IVSAEHVEGA
610 620 630 640 650 660
DKLLRLQLDI GSEQRQVFAG IKSAYAPEDL VGRLTVMVAN LEPRKMKFGM SEGMVLAAGP
670 680
GGKDIWLLQP DSGAQPGMQV K