Q2RK78

PR
Gene name
murC
Protein name
UDP-N-acetylmuramate--L-alanine ligase
Names
UDP-N-acetylmuramoyl-L-alanine synthetase
Species
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
KEGG Pathway
mta:Moth_0844
EC number
6.3.2.8: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2RK78

Entry ID Method Resolution Chain Position Source
AF-Q2RK78-F1 Predicted AlphaFoldDB

No variants for Q2RK78

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2RK78

No associated diseases with Q2RK78

3 regional properties for Q2RK78

Type Name Position InterPro Accession
domain Mur ligase, C-terminal 285 - 349 IPR004101
domain Mur ligase, central 100 - 227 IPR013221
conserved_site Folylpolyglutamate synthetase, conserved site 98 - 121 IPR018109

Functions

Description
EC Number 6.3.2.8 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
UDP-N-acetylmuramate-L-alanine ligase activity Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
regulation of cell shape Any process that modulates the surface configuration of a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADLETGGWT HFVGIGGVGM SALARILLAQ GYRVSGSDPK ENQFTRSLEA AGAIIYHQHD
70 80 90 100 110 120
AANLAPGVQE VVISSAVPSS NPEVVAARQR SLPVVKRGEL LARLFNARRG IAVAGAHGKT
130 140 150 160 170 180
TTSALVALVM KEGGLEPAAV IGGYVREFAS NAYPGRGDFL VAEADESDGS FLWLKPEIAL
190 200 210 220 230 240
ITNIEADHLE HYGSLDRIVA AFKDFIDQIR PGGKAILCAE DPRVAGLVAC SPRQVITYGL
250 260 270 280 290 300
NGRPDYRATG VQMAGMGGRA AIYYREQYLG QLTMAVPGRH NILNALGAIA AGHQLGIPFA
310 320 330 340 350 360
VMARALGQFR GVGRRFEILW DDGTTRVVDD YAHHPTEIRA TLAAASQVGA KRVVAVFQPH
370 380 390 400 410 420
RYTRTHHLYR EFGQAFRQAD VVIVNDIYPA GEAPLPGVNS QLITGEIKGS GHQQVYYLPT
430 440 450 460
LEETLAFLKK SCRPGDLVLT LGAGDVWRVG MGLAQYLEAK QILPGVGA