Q2RHZ3

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
KEGG Pathway
mta:Moth_1644
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

393-471 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2RHZ3

Entry ID Method Resolution Chain Position Source
AF-Q2RHZ3-F1 Predicted AlphaFoldDB

No variants for Q2RHZ3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2RHZ3

No associated diseases with Q2RHZ3

4 regional properties for Q2RHZ3

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 870 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 657 - 700 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 560 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 713 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTGNELRERF LKFFASKGHT IVHSSSLVPA NDPTLLFTNA GMVQFKDVYL GLDRRPFTRA
70 80 90 100 110 120
TTAQKCVRAG GKHNDLDTVG RTARHHTFFE MLGNFSFGDY FKREAITYAW EFLTRVLELP
130 140 150 160 170 180
PERLWVTVYQ EDDEAYQLWQ EIAGIPAERI VRMGEKDNFW AMGDTGPCGP CSEIIYDRGP
190 200 210 220 230 240
EHACSSTPCA LGACDCDRWL EIWNLVFMQY ERDSNGNLSP LPRPSIDTGM GLERVASVLQ
250 260 270 280 290 300
GVDSNFDTDL IAPLIKAVEK ITGRTYDPGE AGFPFRVIAD HARSCTFLIA DGILPGNEGR
310 320 330 340 350 360
SYVLRRILRR AARFGKALGI DEPFLYRLVD TVVAIMGGAY PEVAEQQEHI ARVIEQEEIR
370 380 390 400 410 420
FHETLNDGLK VLNGILERAR QEGREVVSGL EAFTLYDTYG FPLDLTEEIA GEGGFKVDRD
430 440 450 460 470 480
GFEKAMAAQR ERARAAREDV KAYDFALAFA GALEDISGTA FTGYDQLEDK GTVLALFQEG
490 500 510 520 530 540
ARVTSLEANA TGYVVLDRTP CYPEGGGQVG DRGELKWSGG QARVEDTRRL PDGKIVHQIN
550 560 570 580 590 600
VTAGTLVVGQ EVEIAVDRER RQATARNHTV THLLHRALKN ILGEHVNQAG SLVTPERLRF
610 620 630 640 650 660
DFTHFAPLTG EELRAVEAEV NQKILANLPV TTLETSYQEA KAMGATALFG EKYGERVRVV
670 680 690 700 710 720
KIDAYSMELC GGTHLGSTSE AGSFRLVSES GIGAGVRRVE AVTGAAALEM ALQDRQELAT
730 740 750 760 770 780
IAGLLKVPPD QAIQRVRHLL EQNKENEREL AQLRNELASY TIDKLLDRVQ EVAGVPVLPA
790 800 810 820 830 840
RVQITDPEAL REMAERLRSR LGSGVVILGS QHNGRVNFVA MVSKDLVQRG IHAGNLLREV
850 860 870 880
ARIASGGGGG RADMAQAGGK DPGKLDQALA YSLKVVAAQV R