Q2RG98
Gene name |
leuC |
Protein name |
3-isopropylmalate dehydratase large subunit |
Names |
Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase |
Species |
Moorella thermoacetica (strain ATCC 39073 / JCM 9320) |
KEGG Pathway |
mta:Moth_2254 |
EC number |
4.2.1.33: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2RG98
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2RG98-F1 | Predicted | AlphaFoldDB |
No variants for Q2RG98
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2RG98 | |||||
No associated diseases with Q2RG98
4 regional properties for Q2RG98
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 7 - 411 | IPR001030 |
| binding_site | Aconitase family, 4Fe-4S cluster binding site | 292 - 308 | IPR018136-1 |
| binding_site | Aconitase family, 4Fe-4S cluster binding site | 352 - 365 | IPR018136-2 |
| domain | 3-Isopropylmalate dehydratase, catalytic domain | 31 - 413 | IPR033941 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.33 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3-isopropylmalate dehydratase activity | Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. |
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| leucine biosynthetic process | The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGMTITEKIL | AAHAGLKAVE | PGQLINAKVD | LALGNDITAP | LAIQEFKKLG | VKKVFDPERV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLVPDHFTPA | KDIKSAEQAK | ILRDFAREQG | LTHYFEIGRM | GIEHCLLPEA | GLVGPGDLVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GADSHTCTYG | ALGAFATGVG | STDLAAAMAT | GELWFKVPET | ILFRYHGKLK | PWVGGKDLIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YTIGRIGVDG | ARYMAMEFTG | EAITNLSMEG | RFTMANMAIE | AGGKNGIFPV | DEKTVEYIRG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLQRDYRIYQ | SDPDARYNQE | IDIDASKIEP | QVALPHLPEN | ARSVKEIGEI | KIDQVVIGSC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TNGRLEDLRV | AAQILKGQKV | HPEVRLIVIP | GTQQIYAAAL | AEGLIATFIE | AGAAVSTPTC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GPCLGGHMGI | LAKGERALAT | TNRNFVGRMG | HPESEVYLAG | PAVAAASAVK | GRIAAPEEVV |
| K |