Q2QLH2
PR
Gene name |
WNT2 |
Protein name |
Protein Wnt-2 |
Names |
|
Species |
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) |
KEGG Pathway |
oga:100946400 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2QLH2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2QLH2-F1 | Predicted | AlphaFoldDB |
No variants for Q2QLH2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2QLH2 | |||||
No associated diseases with Q2QLH2
1 regional properties for Q2QLH2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Wnt protein, conserved site | 206 - 215 | IPR018161 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| extrinsic component of external side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytokine activity | The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. |
| frizzled binding | Binding to a frizzled (fz) receptor. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| atrial cardiac muscle tissue morphogenesis | The process in which the anatomical structure of cardiac atrium muscle is generated and organized. |
| canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | Any canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation. |
| cardiac epithelial to mesenchymal transition | A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
| cardiac muscle cell proliferation | The expansion of a cardiac muscle cell population by cell division. |
| cell proliferation in midbrain | The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. |
| cellular response to transforming growth factor beta stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. |
| epithelial cell proliferation involved in lung morphogenesis | The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. |
| labyrinthine layer blood vessel development | The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. |
| lung induction | The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung. |
| mammary gland epithelium development | The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. |
| mesenchymal cell proliferation | The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. |
| positive regulation of cardiac muscle cell proliferation | Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. |
| positive regulation of DNA-binding transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| positive regulation of epithelial cell proliferation involved in lung morphogenesis | Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. |
| positive regulation of fibroblast proliferation | Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. |
| positive regulation of mesenchymal cell proliferation | The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. |
| positive regulation of neurogenesis | Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNAPLCGIWL | WLPLLLTWLT | PEVSSSWWYM | RATSGSSRVM | CDNVPGLVSR | QRQLCHRHPD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VMRAIGLGVA | EWTAECQHQF | RQHRWNCNTL | DRDHSLFGRV | LLRSSRESAF | VYAISSAGVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FAITRACSQG | ELKSCSCDPK | KKGTAKDSKG | TFDWGGCSDN | IDYGIKFARA | FVDAKERKGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DARALMNLHN | NRAGRKAVKR | FLKQECKCHG | VSGSCTLRTC | WLAMADFRKT | GSYLWRKYNG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AIQVVMNQDG | TGFTVANKRF | KKPTKNDLVY | FENSPDYCIR | DREAGSLGTA | GRVCNLTSRG |
| 310 | 320 | 330 | 340 | 350 | |
| MDSCEVMCCG | RGYDTSRVTR | MTKCECKFHW | CCAVRCQDCL | EALDVHTCKA | PKNADWTTPT |