Q2QDF1

PR
Gene name
DNASE1L1
Protein name
Deoxyribonuclease-1-like 1
Names
DNase X, Deoxyribonuclease I-like 1, DNase I-like 1
Species
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

106-178 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2QDF1

Entry ID Method Resolution Chain Position Source
AF-Q2QDF1-F1 Predicted AlphaFoldDB

No variants for Q2QDF1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2QDF1

No associated diseases with Q2QDF1

3 regional properties for Q2QDF1

Type Name Position InterPro Accession
domain Endonuclease/exonuclease/phosphatase 24 - 265 IPR005135
active_site Deoxyribonuclease I, active site 144 - 164 IPR018057
conserved_site Deoxyribonuclease I, conservied site 181 - 188 IPR033125

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

2 GO annotations of molecular function

Name Definition
deoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

1 GO annotations of biological process

Name Definition
DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHYPTALLFL ILVNGAQAFR ICAFNAQRLT LAKVAREQVM DTLVRILARC DIMVLQEVVD
70 80 90 100 110 120
SSGSAIPLLL RELNRFDASG PYSTLSSPQL GRTTYVETYV YFYRSHKTQV LSSYVYNDED
130 140 150 160 170 180
DVFAREPFVA QFSLPSDVLP SLVLVPLHTT PKAVEKELNA LYDVFLEVSQ HWQSKDVILL
190 200 210 220 230 240
GDFNADCASL TKKRLDKLEL RTEPGFHWVI ADGEDTTVRA STHCAYDRIV LHGERCRSLL
250 260 270 280 290 300
HTAAAFDFPT TFQLTEEEAL NISDHYPVEV ELKLSQAHSV QPLSLTVLLL LSLLSPQLCP
AT