Q2PIU8
Gene name |
tof1 (AO090206000054) |
Protein name |
Topoisomerase 1-associated factor 1 |
Names |
|
Species |
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) |
KEGG Pathway |
aor:AO090206000054 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2PIU8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2PIU8-F1 | Predicted | AlphaFoldDB |
No variants for Q2PIU8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2PIU8 | |||||
No associated diseases with Q2PIU8
4 regional properties for Q2PIU8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 359 - 409 | IPR001611 |
| repeat | Leucine-rich repeat, typical subtype | 359 - 378 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 379 - 402 | IPR003591-2 |
| domain | Endonuclease/exonuclease/phosphatase | 508 - 818 | IPR005135 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| negative regulation of DNA replication | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNDEAVAFSQ | AVQVVDPDVR | AHVYSLVTAL | GGFNGEDADR | YVLGDDALAC | LRDIRRWLKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YDEKYHRMDV | ARCLGEANLV | NGDLLPIFSL | WWSTGQKSKY | MSRIALACLE | LLVPLTWPLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VHGEMTVNHH | RHFPYLQHAQ | VSYKRGLLSR | GDLNFLRTII | RIGLPSMAVP | RSERTTRDDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILKLMLYLLR | NIVVIAPNAR | LAADGDEEET | SRSATINAFQ | AQDVFALLLT | MCSNVGDDFN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MQDVILLEIL | FHLVKGVNVQ | KLFMDDAQRS | AKHTDELDTL | LKQESSLRRE | YAKNAPTRHG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RFGTMIWVKR | DDAKVSTVSG | QDVLKDSQAT | LQKMDESKKW | NRPQPRKTHE | DSVLNNDFST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PAHLNSTASR | NLRMFVEEFL | DSGFNPLFTH | VRKALEREAD | RVVPINSRQF | FYTVAWFLDA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ERARRARQQE | MHLQNGKPMK | ELERDGFGLV | ASVLDQETLV | FLNRSMQISF | DQKDWEDLNA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EMRCFTQILL | TVQEMTQSLL | EEDQEIAENI | QNRIFYEETT | HDRVLAIMRE | YKGQGFGYLD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ACTELSHVFL | RMLERYSKEN | VDMQVRSRRR | SRRKNMETQV | AAPEDNNEEH | ASDDEDIMEA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ERICRERKFD | FKRFAAKFCN | QKCVDTFVAF | TKFFRELNSD | QLKRAHRYFY | RIAFKQEMSV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLFRVDILNL | FYTMIKGPGA | MDSSKPIFKE | WEELVRQVIR | RMIKKIDQRP | ALITELLFSK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MNSTLFYLEY | GHERQTLPSV | RRAPAELEVN | PSEATTQEDK | IKIVIGALVM | DGQADLVAWV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SNVLGTAAEE | RESWEAYEDA | QRDEAQGAPR | APNPMIAVLP | HDDACKQAMY | FNAKLRLLMT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LVGFERLGME | DVVGASWVVP | SSQGSKDLKG | IKLTIDKCLE | DPYTGDIEHD | PRQMLRRKYK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PDDKEHNRQT | TLDVDFGSES | EGEDVPDGPL | FPPNPRSKAN | APNDSKTRRK | NREAVGEREP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IDEDTLEARR | KARQENTRAR | LAKIKSELFV | HASDDESDEE | ADKEFFDLEE | KRRKEQAARV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RKALLTGVVD | EIGRKANKKS | ERKRLSNSGK | SDTQSKRQRR | GRTTEALDED | DDIIMDGAVA |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RSSDHATEDD | ENTSATSDED | DEFDFDDNLA | FRRDRDLDRD | PVLPSHAEDM | QPTDTRELRD |
| 1150 | 1160 | ||||
| NDENAPVATL | ARRRLRAGFV | IDSDSE |