Q2PG45

PR
Gene name
TBXAS1 (CYP5, CYP5A1, QccE-11311)
Protein name
Thromboxane-A synthase
Names
TXA synthase, TXS, Cytochrome P450 5A1, Hydroperoxy icosatetraenoate dehydratase
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
4.2.1.152: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

270-352 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2PG45

Entry ID Method Resolution Chain Position Source
AF-Q2PG45-F1 Predicted AlphaFoldDB

No variants for Q2PG45

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2PG45

No associated diseases with Q2PG45

1 regional properties for Q2PG45

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 472 - 481 IPR017972

Functions

Description
EC Number 4.2.1.152 Hydro-lyases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

7 GO annotations of molecular function

Name Definition
12-hydroxyheptadecatrienoic acid synthase activity Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA).
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
hydroperoxy icosatetraenoate dehydratase activity A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O.
iron ion binding Binding to an iron (Fe) ion.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
thromboxane-A synthase activity Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2).

2 GO annotations of biological process

Name Definition
icosanoid metabolic process The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.
prostaglandin biosynthetic process The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS PFIGNLMFFR
70 80 90 100 110 120
QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL VENFSNFTNR MASGLEFKSV
130 140 150 160 170 180
ADSVLFLRDK RWEEVRGALM SAFSPEKLNE MTPLISQACD LLLAHLKRYA ESGDAFDIQR
190 200 210 220 230 240
CYRNYTTDVV ASVAFGTPVD SQQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA
250 260 270 280 290 300
RILPNKNRDE LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PVGVQDFDMV
310 320 330 340 350 360
GDVFSSTRCK PNPSRQHQAG PMARPLTVDE IVGQAFIFLI AGYEIVTNTL SFATYLLATN
370 380 390 400 410 420
PDCQEKLLRE VDLFKEKHMV PEFCSLEEGL PYLDMVIAET LRMYPPAFRF TREAAQDCEV
430 440 450 460 470 480
LGQRIPAGAV LEMAVGALHH DPEHWPSPET FNPERFTAEA QQQHRPFTYL PFGAGPRSCL
490 500 510 520 530
GVRLGLLEVK LTLLHVLHKF QFQACPETQV PLQLESKSAL GPKNGVYIKI VSR