Q2NVY6

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Sodalis glossinidius (strain morsitans)
KEGG Pathway
sgl:SG0414
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

792-876 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2NVY6

Entry ID Method Resolution Chain Position Source
AF-Q2NVY6-F1 Predicted AlphaFoldDB

No variants for Q2NVY6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2NVY6

No associated diseases with Q2NVY6

4 regional properties for Q2NVY6

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 49 - 60 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 20 - 662 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 711 - 862 IPR013155
domain Isoleucyl tRNA synthetase type 2, anticodon-binding domain 664 - 845 IPR033709

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDYKNTLNL PDTGFPMRGD LAKREPGMLE RWYEQDLYGI ICQARKGKKT FILHDGPPYA
70 80 90 100 110 120
NGSIHIGHSV NKILKDIIIK SKGLMGYDSP YVPGWDCHGL PIELKVEQLI GKPGEKVSAA
130 140 150 160 170 180
EFRTACRRYA AEQVEGQKKD FIRLGVLGDW EHPYLTMNFA TEANIIRALG KIIANGHLHK
190 200 210 220 230 240
GAKPVHWCID CRSALAEAEV EYYDRTSPSI DVAFAADDVR AVAAKFGAAD FAGQISLIIW
250 260 270 280 290 300
TTTPWTLPAN RAIAVHPDFD YQLVEVEGQG YILAADLVDS VMARAGITCW TVLGSAKGSA
310 320 330 340 350 360
LELLRFRHPF MGFDVPAILG QHVTLDAGTG AVHTAPGHGP DDYVIGQQYG LEVANPVGPD
370 380 390 400 410 420
GCYLPGTLPA LDGLQVFKAN DVVINLLCDS GALLHVEKLQ HSYPHCWRHK TSIIFRATPQ
430 440 450 460 470 480
WFVSMDQRGL RKQSLAEIKD VQWIPGWGQA RIETMVANRP DWCISRQRTW GVPMALFVHN
490 500 510 520 530 540
ETEALHPRTI ELMESVAQRV EQDGIQAWWD LDPAEILGDD AAHYHKVPDT LDVWFDSGST
550 560 570 580 590 600
HSSIVAVRPE FEGHAPDMYL EGSDQHRGWF MSSLMISTAM HGKAPYRQVL THGFTVDGQG
610 620 630 640 650 660
RKMSKSVGNV VSPQQVMDKL GADILRLWVA STDYTGEMAV SDEILKRSAD AYRRIRNTAR
670 680 690 700 710 720
FLLANLNGFD PARHSVSPEQ MVVLDRWAVG RAQAAQAEIV AAYDSYDFHN VVQRMMQFCS
730 740 750 760 770 780
VEMGSFYLDI IKDRQYTTKA DSIARRSCQT ALYHIIEALV RWMAPIMSFT ADEIWGFMPG
790 800 810 820 830 840
ERAQYVFTEE WYDGLFGLDA AQPLNDAYWQ ILLQVRSETN KVIEQARADK RIGGSLEARV
850 860 870 880 890 900
TLYAEPDLAA SLRELGDELY FTLLTSNAVV ADYADAGDDA VQCEGLKGLK IALAKAEGEK
910 920 930
CPRCWHYETD IGQHADHPEI CGRCVTNVAG PGEERKFV