Q2N811

PR
Gene name
ruvA
Protein name
Holliday junction ATP-dependent DNA helicase RuvA
Names
Species
Erythrobacter litoralis (strain HTCC2594)
KEGG Pathway
eli:ELI_10440
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

104-184 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2N811

Entry ID Method Resolution Chain Position Source
AF-Q2N811-F1 Predicted AlphaFoldDB

No variants for Q2N811

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2N811

No associated diseases with Q2N811

4 regional properties for Q2N811

Type Name Position InterPro Accession
domain Helix-hairpin-helix DNA-binding motif, class 1 71 - 90 IPR003583-1
domain Helix-hairpin-helix DNA-binding motif, class 1 106 - 125 IPR003583-2
domain Holliday junction DNA helicase RuvA, C-terminal 158 - 200 IPR011114
domain DNA helicase, Holliday junction RuvA type, domain I, bacterial 1 - 60 IPR013849

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
Holliday junction helicase complex A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
four-way junction helicase activity Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
SOS response An error-prone process for repairing damaged microbial DNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIAKLKGLLD ETGTDWAVID VSGVGYLVHC SSKSLAALGE VGEACTVYTD LQVSENDMRL
70 80 90 100 110 120
LGFAEASERD WFRLLTQVQG VGSKVALAIL SALSTEEVQT ACANGDAAMV ARAQGVGPKL
130 140 150 160 170 180
AGRIVNELKD KAGALPSAPG GAAMAANPAG GASADAVSAL ENLGFKPAIA ARAVATAQGE
190
LGEGASESEL IRVALKRAAG