Q2N5Q5

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Erythrobacter litoralis (strain HTCC2594)
KEGG Pathway
eli:ELI_14470
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

166-243 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2N5Q5

Entry ID Method Resolution Chain Position Source
AF-Q2N5Q5-F1 Predicted AlphaFoldDB

No variants for Q2N5Q5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2N5Q5

No associated diseases with Q2N5Q5

7 regional properties for Q2N5Q5

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 345 - 392 IPR000722-1
domain RNA polymerase, alpha subunit 389 - 486 IPR000722-2
domain RNA polymerase, N-terminal 236 - 515 IPR006592
domain RNA polymerase Rpb1, domain 3 490 - 655 IPR007066
domain RNA polymerase Rpb1, domain 1 15 - 343 IPR007080
domain RNA polymerase Rpb1, domain 5 773 - 1316 IPR007081
domain RNA polymerase Rpb1, domain 4 684 - 763 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNELTKFTNQ LAKPETFDQI QIGIASPERI RSWSFGEIKK PETINYRTFK PERDGLFCAR
70 80 90 100 110 120
IFGPVKDYEC LCGKYKRMKY KGVVCEKCGV EVTVTKVRRE RMGHIELAAP VAHIWFLKSL
130 140 150 160 170 180
PSRIGLLLDM QLKQLERVLY FEHYIVTEPG LTPLEKFQLL TEDELLEAQD EYGEDAFSAG
190 200 210 220 230 240
IGAEAVKFML MDLDLEQEKE DLLEELATTK SKLKPAKIIK RLKVVESFIE SGNRPEWMIL
250 260 270 280 290 300
EVVPVIPPEL RPLVPLDGGR FATSDLNDLY RRVINRNNRL KRLIELRAPD IIVRNEKRML
310 320 330 340 350 360
QESVDALFDN GRRGRVITGA NKRPLKSLSD MLKGKQGRFR QNLLGKRVDY SGRSVIVTGP
370 380 390 400 410 420
ELKLHQCGLP KKMALELFKP FIYARLDAKG LSMTLKQAKK WVEKERKEVW DILDEVIREH
430 440 450 460 470 480
PVLLNRAPTL HRLGIQAFEP VLIEGKAIQL HPLVCSAFNA DFDGDQMAVH VPLSLEAQLE
490 500 510 520 530 540
ARVLMMSTNN ILSPANGKPI IVPSQDMVLG LYYLSMERQE KTPEYIEEKD GTKIEKLPRF
550 560 570 580 590 600
ADMAEVHQAL ETKSVTLHTR IIARVPQADE DGKPEMKRFV TTPGRMLIGE CLPKNHKVPY
610 620 630 640 650 660
DIVNRLLTKK EIGDVIDQVY RHTGQKDTVL FADAIMVLGF RHAFKAGISF GKDDMIIPDS
670 680 690 700 710 720
KEGMIEDTKK QVADYEQQYQ DGLITQQEKY NKVIDAWSRC GDQVAEAMMD EIKSQKFDKD
730 740 750 760 770 780
GKESEINSIY MMSHSGARGS PAQMKQLAGM RGLMAKPSGE IIENPIISNF KEGLTVLEYF
790 800 810 820 830 840
NSTHGARKGL ADTALKTANS GYLTRRLVDV SQDCVIVEED CKTDNALEMR AIVQGGSVIA
850 860 870 880 890 900
SLGERILGRT LVDDLVNAKT DEVIVKAGTL LDEPMVKAIE EAEVQVARIR SPLVCEADQG
910 920 930 940 950 960
VCATCYGRDL ARGTPVNIGE AVGVIAAQSI GEPGTQLTMR TFHIGGAAQL NETSHLESIS
970 980 990 1000 1010 1020
DGKVEYRDMP TITDKKGRIL SLARNGELAV IDAEGREREI HKVPYGTVLM HKDGAKVKEG
1030 1040 1050 1060 1070 1080
DRLAEWDPFS LPIITEQSGV VKYQDLIEGT TLEEQTDDAT GIAQRVVTEN RATGRKKKED
1090 1100 1110 1120 1130 1140
LRPRLTLLSE GQSEDETEAQ RYLLAPGTTL SVTDGQTVEA GDILARASRE AAKTRDITGG
1150 1160 1170 1180 1190 1200
LPRVAELFEA RVPKDNAVIA KISGKIEFVR EYKAKRKIAI VPEEGEAVDY LIPKTKVIDV
1210 1220 1230 1240 1250 1260
QEGDFVKKGD TLISGSPNPH DILDVLGVEA LAEYLCTEIQ EVYRLQGVKI NDKHIEVIVR
1270 1280 1290 1300 1310 1320
QMLQKVEITD GGDTVLLPGE QVDRDEMDEA NAKLGRGKKP ATGNPVLLGI TKASLQTRSF
1330 1340 1350 1360 1370 1380
ISAASFQETT RVLTQASVEG KKDTLIGLKE NVIVGRLIPA GTGAGMNRMR VTASARDAAL
1390 1400 1410 1420 1430
RAQWKKQQEK LAAADEAAMA AEKEPEAEVM DADAMAAAMG GDSAGGDTKP EAPEASEE