Q2MHH3

PR
Gene name
ku70
Protein name
ATP-dependent DNA helicase II subunit 1
Names
ATP-dependent DNA helicase II subunit Ku70
Species
Aspergillus sojae
KEGG Pathway
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2MHH3

Entry ID Method Resolution Chain Position Source
AF-Q2MHH3-F1 Predicted AlphaFoldDB

No variants for Q2MHH3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2MHH3

No associated diseases with Q2MHH3

5 regional properties for Q2MHH3

Type Name Position InterPro Accession
domain SAP domain 618 - 652 IPR003034
domain Ku70/Ku80 C-terminal arm 500 - 590 IPR005160
domain Ku70/Ku80, N-terminal alpha/beta 31 - 240 IPR005161
domain Ku70/Ku80 beta-barrel domain 286 - 479 IPR006164
domain Ku70, core domain 279 - 557 IPR047087

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Chromosome, telomere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
Ku70:Ku80 complex Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
damaged DNA binding Binding to damaged DNA.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
telomeric DNA binding Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.

3 GO annotations of biological process

Name Definition
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADEDQYRGD DQIDEEEEEI DESGYKTVKD AVLFAIEVSD SMLTPRPSSD SKKPAEESPT
70 80 90 100 110 120
TAALKCAYHL MQQRIISNPR DMIGVLLYGT QASKFYDEDE NSRGDLSYPH CYLFTDLDVP
130 140 150 160 170 180
SAQEVKNLRA LAQDGDESED VLKASGERVS MANVLFCANQ IFTSKAPNFL SRRLFIVTDN
190 200 210 220 230 240
DDPHGDNKSL RSAATVRAKD LYDLGVTIEL FPISRPDHEF DTARFYDDII YKASPSDPDA
250 260 270 280 290 300
PAYLQTDSKA SPATGDGISL LSTLLSSINS RSVPRRAQFS NIPLELGPNF KISVSGYLLF
310 320 330 340 350 360
KRQAPARNSF IWLGGEQPQI VKGVTTQIAD DTARTIEKWE IKKAYKFGGD QVAFTPEEMK
370 380 390 400 410 420
SLRNFGDPVI RIIGFKPLSA LPFWANIKHP SFIYPSEEDF VGSTRVFSAL HQTLLRDKKA
430 440 450 460 470 480
ALVWFIARKN ASPVLGAMVA GEEKLDESGV QKFPPGMWII PLPFADDVRQ NPETTLHVAP
490 500 510 520 530 540
EPLIDQMRYI VQQLQLPKAS YDPFKYPNPS LQWHYRILQA LALDEDLPEK PEDKTLPRYR
550 560 570 580 590 600
QIDKRTGDYV LSWADELEKQ YAKISAHGPK STLVERSAKD RTSEVEDAAP KPYKKVKVET
610 620 630 640 650
DEQGVEDVVR APYQKGSLSK LTVPVLKNFL KAHGRSAAGK KKELVERVEE YLEQK