AiPD: Autoinhibited Protein Database

Q2M3C6

Gene name	TMEM266
Protein name	Transmembrane protein 266
Names	hTMEM266, HV1-related protein 1, HsHVRP1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:123591
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

284-505 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

284-505 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q2M3C6

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q2M3C6-F1	Predicted				AlphaFoldDB

475 variants for Q2M3C6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs749288406 CA7672961	2	A>T		No	ClinGen ExAC gnomAD
CA393628399 rs1364563968	2	A>V		No	ClinGen gnomAD
CA7672962 rs768613347	5	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs114291110 CA7672963	6	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs114291110 CA7672964	6	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369334168 CA7672965	7	F>L		No	ClinGen ESP ExAC gnomAD
CA393628464 rs1489075341	8	N>I		No	ClinGen TOPMed
CA393628496 rs1353512983	10	T>I		No	ClinGen TOPMed gnomAD
CA393628498 rs1353512983	10	T>S		No	ClinGen TOPMed gnomAD
rs1319691126 CA393628506	11	N>S		No	ClinGen TOPMed
rs1398266134 CA393629039	13	Q>H		No	ClinGen gnomAD
rs928955471 CA273417228	16	I>V		No	ClinGen gnomAD
CA7672982 rs747935485	18	G>R		No	ClinGen ExAC TOPMed gnomAD
rs771915334 CA7672984	20	I>V		No	ClinGen ExAC gnomAD
CA393629102 rs1219497543	23	V>A		No	ClinGen gnomAD
CA7672985 rs370445042	25	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA273417243 rs891192320	27	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	28	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771077402 CA7672987	29	Q>*		No	ClinGen ExAC gnomAD
rs776711597 CA7672988	32	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA393629175 rs1251305530	34	T>A		No	ClinGen gnomAD
CA393629179 rs1486216365	34	T>I		No	ClinGen gnomAD
TCGA novel	35	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393629198 rs1423735164	37	I>V		No	ClinGen gnomAD
rs1044547272 CA273417252	38	A>S		No	ClinGen Ensembl
CA393629210 rs1170600566	39	P>S		No	ClinGen gnomAD
CA393629219 rs1427462938	40	V>G		No	ClinGen gnomAD
CA7672991 rs776195376	41	Q>R		No	ClinGen ExAC gnomAD
rs1596128064 CA393629228	42	L>V		No	ClinGen Ensembl
rs763386965 CA7672992	47	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs540647010 CA7672995	48	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7672994 rs540647010	48	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200391773 CA7672993	48	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1596128082 CA393629281	50	L>W		No	ClinGen Ensembl
COSM1243122 rs1382699944 CA393629286	51	P>S	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs753279696 CA7672997	52	L>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	54	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7672998 rs754552309	55	V>I		No	ClinGen ExAC gnomAD
CA7673000 rs778812089	56	D>H		No	ClinGen ExAC TOPMed gnomAD
CA7672999 rs778812089	56	D>N		No	ClinGen ExAC TOPMed gnomAD
CA393629319 rs1348785407	57	L>F		No	ClinGen gnomAD
TCGA novel	57	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393629328 rs1213547282	58	S>C		No	ClinGen gnomAD
TCGA novel	58	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758162612 CA7673001	59	T>M		No	ClinGen ExAC TOPMed gnomAD
CA7673003 rs200729077	60	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA7673004 rs372015383	62	S>L		No	ClinGen ESP ExAC gnomAD
rs745928129 CA7673006	63	Q>R		No	ClinGen ExAC gnomAD
CA7673007 rs374327200	64	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs776108925 CA7673008	64	L>H		No	ClinGen ExAC gnomAD
TCGA novel	66	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7673009 rs201363747	67	N>S		No	ClinGen ExAC TOPMed gnomAD
rs764539432 CA7673010	68	L>V		No	ClinGen ExAC TOPMed gnomAD
CA7673012 rs762095902 COSM3504157	70	E>K	Variant assessed as Somatic; 4.97e-05 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs762095902 CA393629391	70	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA273417362 rs971145002	73	Q>E		No	ClinGen TOPMed
rs1567163930 CA393629424	74	R>T		No	ClinGen Ensembl
TCGA novel	75	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7673014 rs753553131	75	E>K		No	ClinGen ExAC gnomAD
rs751493153 CA7673038	77	S>F		No	ClinGen ExAC gnomAD
rs1178787685 CA393630900	80	L>M		No	ClinGen gnomAD
CA393630902 rs1409454559	80	L>P		No	ClinGen gnomAD
rs368599050 CA7673039	82	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7673040 rs375702425	84	C>Y		No	ClinGen ESP ExAC gnomAD
rs756338158 CA7673042	85	G>E		No	ClinGen ExAC gnomAD
CA7673041 rs750274766	85	G>W		No	ClinGen ExAC TOPMed gnomAD
rs976221083 CA273427227	87	R>T		No	ClinGen TOPMed gnomAD
CA7673043 rs780436455	88	A>V		No	ClinGen ExAC gnomAD
CA7673046 rs779440839	90	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7673047 rs779440839	90	V>M		No	ClinGen ExAC TOPMed gnomAD
CA7673048 rs772651590	92	Q>P		No	ClinGen ExAC gnomAD
CA7673049 rs201537562	93	V>G		No	ClinGen ExAC gnomAD
TCGA novel	95	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA273427274 rs905116019	96	L>F		No	ClinGen Ensembl
rs1439192569 CA393631009	97	S>N		No	ClinGen TOPMed
CA393631013 rs1596140403	97	S>R		No	ClinGen Ensembl
CA393631030 rs1163659376	100	L>P		No	ClinGen TOPMed
CA7673050 rs761044327	100	L>V		No	ClinGen ExAC TOPMed gnomAD
CA393631064 rs1307762448	105	V>L		No	ClinGen gnomAD
rs937884671 CA273427280	106	A>S		No	ClinGen Ensembl
rs1206140171 CA393631097	110	L>S		No	ClinGen gnomAD
CA393631112 rs1596140418	112	V>G		No	ClinGen Ensembl
rs1387952651 CA393631118	113	I>S		No	ClinGen TOPMed
rs564550568 CA7673052	118	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs762495527 CA7673053	118	E>V		No	ClinGen ExAC gnomAD
TCGA novel	122	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	123	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs186201023 CA7673055	124	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA393631206 rs1596140445	127	Q>H		No	ClinGen Ensembl
rs1311429568 CA393631231	129	S>P		No	ClinGen TOPMed
rs780642775 CA7673074	131	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs550666214 CA273429851 COSM1939732	136	G>S	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1413079047 CA393631336	136	G>V		No	ClinGen gnomAD
CA7673077 rs369743897	137	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA393631354 rs1436655378	138	I>F		No	ClinGen gnomAD
rs747394893 CA273429879	140	W>S		No	ClinGen Ensembl
CA7673078 rs149378942	141	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	144	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1300459257 CA393631441	144	V>L		No	ClinGen TOPMed gnomAD
rs765514600 CA7673081	147	S>F		No	ClinGen ExAC gnomAD
CA7673083 rs758543246	148	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1210730826 CA393631518	150	F>L		No	ClinGen gnomAD
CA393631548 rs1423749413	152	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	153	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393632285 rs1490068727	153	T>S		No	ClinGen TOPMed gnomAD
CA393632287 rs1198676505	154	V>I		No	ClinGen TOPMed gnomAD
TCGA novel	155	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1364721120 CA393632300	156	R>P		No	ClinGen gnomAD
rs200133901 CA7673100	157	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA393632311 rs1157629800	158	V>L		No	ClinGen gnomAD
rs1461522447 CA393632351	164	D>Y		No	ClinGen gnomAD
rs751672162 CA7673103	166	I>V		No	ClinGen ExAC gnomAD
rs781729675 CA7673105	167	E>G		No	ClinGen ExAC gnomAD
rs1329339593 CA393632371	167	E>K		No	ClinGen TOPMed gnomAD
COSM3794417 rs1391701952 CA393632442	175	G>R	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA393632448 rs1308649639	176	A>T		No	ClinGen gnomAD
CA7673132 rs199900820	177	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs770518242 CA7673133	178	I>F		No	ClinGen ExAC gnomAD
rs745772345 CA7673135	183	A>S		No	ClinGen ExAC gnomAD
CA393632494 rs1401338642	183	A>V		No	ClinGen gnomAD
rs769651494 CA7673136	184	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs768852904 CA7673139	187	A>E		No	ClinGen ExAC gnomAD
rs750489923 CA7673144	192	N>K		No	ClinGen ExAC
CA7673142 rs767683352	192	N>S		No	ClinGen ExAC gnomAD
CA7673146 rs143442681	196	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs372297539 CA393632598	199	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA393632601 rs1483204532	200	A>T		No	ClinGen gnomAD
CA393632606 rs1208867721	201	I>V		No	ClinGen TOPMed gnomAD
rs1335348644 CA393632622	203	L>F		No	ClinGen TOPMed
rs763810883 CA7673149	205	I>V		No	ClinGen ExAC gnomAD
rs1306408484 CA393632641	206	M>L		No	ClinGen TOPMed
rs1306408484 CA393632640	206	M>V		No	ClinGen TOPMed
rs751309321 CA7673150	207	L>P		No	ClinGen ExAC gnomAD
CA7673151 rs756884747	208	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs919438683 CA273438621	208	R>W		No	ClinGen TOPMed gnomAD
CA393632672 rs1173613981	211	R>G		No	ClinGen gnomAD
CA7673153 rs375197205	211	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs780024822 CA7673155	212	V>A		No	ClinGen ExAC gnomAD
CA7673154 rs756021527	212	V>M		No	ClinGen ExAC gnomAD
rs201845851 CA7673157	215	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7673158 rs774532797	217	D>N		No	ClinGen ExAC gnomAD
TCGA novel	219	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7673185 rs760082559	219	Y>C		No	ClinGen ExAC gnomAD
CA7673187 rs373335165	220	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7673190 rs750081808	226	E>K		No	ClinGen ExAC gnomAD
TCGA novel	228	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7673191 rs760155139	230	V>I		No	ClinGen ExAC gnomAD
rs765824878 CA393632844	234	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA7673193 rs761300568	235	E>K		No	ClinGen ExAC TOPMed gnomAD
rs201795006 CA7673194	236	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs752520367 CA7673196	239	V>F		No	ClinGen ExAC gnomAD
rs778038275 CA7673198	240	I>L		No	ClinGen ExAC gnomAD
rs1339634194 CA393632888	241	Q>R		No	ClinGen gnomAD
CA273442175 rs942023218	242	D>N		No	ClinGen TOPMed gnomAD
CA393632893 rs942023218	242	D>Y		No	ClinGen TOPMed gnomAD
rs769321159 CA273442182	243	E>K		No	ClinGen Ensembl
CA7673200 rs771311818	244	Q>R		No	ClinGen ExAC gnomAD
CA7673201 rs781358139	245	L>M		No	ClinGen ExAC gnomAD
TCGA novel	246	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA273442209 rs912498287	248	L>M		No	ClinGen Ensembl
CA393632937 rs1596153556	249	T>A		No	ClinGen Ensembl
CA393632940 rs772544145	249	T>K		No	ClinGen ExAC TOPMed gnomAD
rs772544145 CA7673203	249	T>M		No	ClinGen ExAC TOPMed gnomAD
CA7673205 rs763347104	250	Q>H		No	ClinGen ExAC gnomAD
rs373481496 CA7673206	255	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	255	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393632982 rs1275777688	255	Q>R		No	ClinGen TOPMed
CA7673207 rs774799142	256	G>E		No	ClinGen ExAC gnomAD
CA273453541 rs745773664	258	E>D		No	ClinGen Ensembl
CA7673241 rs755381660	259	I>V		No	ClinGen ExAC gnomAD
rs1038205774 CA273453545	260	R>P		No	ClinGen TOPMed gnomAD
TCGA novel	260	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7673242 rs779450021	263	R>C		No	ClinGen ExAC gnomAD
TCGA novel	265	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA273453581 rs919752806	267	A>V		No	ClinGen TOPMed
rs1288911821 CA393633370	268	Q>H		No	ClinGen gnomAD
rs748503664 CA7673244	269	Q>R		No	ClinGen ExAC
rs368640787 CA7673246	270	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	272	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1259012618 CA393633394	272	D>A		No	ClinGen gnomAD
CA7673247 rs745484675	272	D>E		No	ClinGen ExAC TOPMed gnomAD
CA393633403 rs1399003093	274	A>T		No	ClinGen gnomAD
CA273453627 rs912590842	275	A>T		No	ClinGen gnomAD
rs1319355096 CA393633413	275	A>V		No	ClinGen TOPMed gnomAD
rs763933915 CA7673252	276	E>*		No	ClinGen ExAC gnomAD
rs763933915 CA7673251	276	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	277	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1045062045 CA273453714	278	E>K		No	ClinGen TOPMed
rs1473851164 CA393633433	279	A>T		No	ClinGen gnomAD
rs1179453474 CA393633444	280	A>V		No	ClinGen gnomAD
CA393633449 rs1455067941	281	L>R		No	ClinGen TOPMed
rs756222990 CA7673256	281	L>V		No	ClinGen ExAC gnomAD
rs753844829 CA7673258	282	Q>E		No	ClinGen ExAC gnomAD
CA393633453 rs1423841610	282	Q>R		No	ClinGen TOPMed gnomAD
rs755147854 CA7673260	283	A>D		No	ClinGen ExAC TOPMed gnomAD
CA7673259 rs755147854	283	A>V		No	ClinGen ExAC TOPMed gnomAD
rs758938634 CA7673263	284	P>A		No	ClinGen ExAC gnomAD
CA393633461 rs758938634	284	P>S		No	ClinGen ExAC gnomAD
CA7673262 rs758938634	284	P>T		No	ClinGen ExAC gnomAD
rs1205460544 CA393633466	285	H>D		No	ClinGen TOPMed
CA7673265 rs747418266	285	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA393633472 rs1596167651	286	V>M		No	ClinGen Ensembl
CA393633479 rs775280219	287	L>F		No	ClinGen ExAC TOPMed gnomAD
CA7673266 rs775280219	287	L>V		No	ClinGen ExAC TOPMed gnomAD
rs748716750 CA7673267	288	S>R		No	ClinGen ExAC gnomAD
rs768333397 CA273453814	290	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7673268 rs768333397	290	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA393633500 rs1596167673	290	P>T		No	ClinGen Ensembl
rs1275770438 CA393633510	292	S>C		No	ClinGen gnomAD
CA393633512 rs1258701126	292	S>I		No	ClinGen gnomAD
rs1596167697 CA393633518	293	R>C		No	ClinGen Ensembl
CA7673269 rs774022859	295	K>E		No	ClinGen ExAC gnomAD
rs931356692 CA273453824	295	K>R		No	ClinGen TOPMed gnomAD
rs1189010322 CA393633536	296	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA393633546 rs1445679423	297	L>W		No	ClinGen gnomAD
CA393633549 rs1443602655	298	E>K		No	ClinGen gnomAD
CA393633564 rs1169026227	300	G>R		No	ClinGen gnomAD
rs1169026227 CA393633563	300	G>S		No	ClinGen gnomAD
CA393633571 rs1375270266	301	T>A		No	ClinGen TOPMed
rs186450715 CA7673271	301	T>M		No	ClinGen 1000Genomes ExAC gnomAD
CA393633589 rs1297551782	303	D>E		No	ClinGen TOPMed gnomAD
rs1427527594 CA393633583	303	D>N		No	ClinGen TOPMed gnomAD
CA393633612 rs1175585508	306	T>M		No	ClinGen TOPMed
rs760576380 CA393633616	307	A>E		No	ClinGen ExAC TOPMed gnomAD
rs1363664433 CA393633613	307	A>T		No	ClinGen TOPMed
rs760576380 CA7673273	307	A>V		No	ClinGen ExAC TOPMed gnomAD
CA393633619 rs1380918095	308	A>P		No	ClinGen TOPMed gnomAD
CA393633620 rs1380918095	308	A>T		No	ClinGen TOPMed gnomAD
CA273453878 rs1012861884	308	A>V		No	ClinGen TOPMed gnomAD
CA273453896 rs907094360	310	S>R		No	ClinGen Ensembl
CA393633640 rs1255025951	311	V>I		No	ClinGen TOPMed
CA393633649 rs1212393768	312	V>A		No	ClinGen TOPMed
CA393633658 rs1225630843	314	E>K		No	ClinGen gnomAD
CA393633679 rs1251306158	317	P>T		No	ClinGen TOPMed gnomAD
CA7673274 rs534350468	320	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA7673288 rs772121084	321	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7673289 rs773264443	322	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs77972713 CA273672628	323	M>L		No	ClinGen Ensembl
rs201419583 CA7673291	324	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs376055659 CA7673293	326	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs545690986 CA7673294	327	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1469362051 CA393508142	327	M>V		No	ClinGen TOPMed gnomAD
CA7673295 rs62030189	329	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA393508168 rs1400969255	330	Y>C		No	ClinGen TOPMed
rs1368776322 CA393508176	331	I>S		No	ClinGen gnomAD
TCGA novel	331	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA273672644 rs940684944	331	I>V		No	ClinGen TOPMed
CA393508191 rs1345428748	333	Q>H		No	ClinGen TOPMed gnomAD
CA7673297 rs780582555	333	Q>R		No	ClinGen ExAC gnomAD
rs1445937923 CA393508206	335	Y>C		No	ClinGen TOPMed
rs1228534096 CA393508213	336	N>S		No	ClinGen gnomAD
CA393508244 rs752158649	340	S>R		No	ClinGen ExAC gnomAD
rs906445212 CA273673602	342	S>N		No	ClinGen TOPMed
rs199679215 CA273673605	342	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7673331 rs201840892	343	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs745636326 CA7673332	344	V>I		No	ClinGen ExAC gnomAD
TCGA novel	345	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1238435717 CA393508289	346	E>Q		No	ClinGen TOPMed
CA273673634 rs746513572	347	P>Q		No	ClinGen Ensembl
rs565357087 CA393508305	348	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7673333 rs565357087	348	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	350	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7673335 rs749473065	351	M>I		No	ClinGen ExAC gnomAD
rs775287535 CA7673334	351	M>T		No	ClinGen ExAC gnomAD
CA393508321 rs1384591676	351	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1361943684 CA393508332	352	V>G		No	ClinGen gnomAD
rs1342622016 CA393508334	353	T>A		No	ClinGen gnomAD
rs1405873500 CA393508337	353	T>S		No	ClinGen TOPMed
rs1230255649 CA393508340	354	T>A		No	ClinGen TOPMed gnomAD
CA7673336 rs542868398	354	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1230255649 CA393508339	354	T>P		No	ClinGen TOPMed gnomAD
rs1438550888 CA393508348	355	A>G		No	ClinGen TOPMed
rs556150508 CA273673666	356	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA273673669 rs201833387	357	I>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201833387 COSM701816 CA7673341	357	I>T	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs532604457 CA7673340	357	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766796985 CA7673342	358	D>A		No	ClinGen ExAC TOPMed gnomAD
CA7673343 rs144785138	359	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1170006208 CA393508367	359	I>V		No	ClinGen gnomAD
CA7673346 rs200903166	360	H>P		No	ClinGen 1000Genomes ExAC gnomAD
CA7673345 rs200903166	360	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA7673344 rs758000358	360	H>Y		No	ClinGen ExAC gnomAD
rs373557591 CA7673347	362	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1045857460 CA273673701	363	N>H		No	ClinGen TOPMed gnomAD
CA393508409 rs1365465747	365	S>F		No	ClinGen gnomAD
CA393508405 rs1335677367	365	S>P		No	ClinGen gnomAD
CA7673350 rs148570844	366	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA393508418 rs1219771804	367	D>A		No	ClinGen gnomAD
CA273673724 rs141364961	368	L>F		No	ClinGen 1000Genomes gnomAD
rs141364961 CA393508424	368	L>V		No	ClinGen 1000Genomes gnomAD
rs1360468378 CA393508428	369	F>L		No	ClinGen TOPMed
CA393508437 rs1334482768	370	S>A		No	ClinGen TOPMed
rs768908339 CA7673354	371	L>P		No	ClinGen ExAC TOPMed gnomAD
rs749093260 CA7673353	371	L>V		No	ClinGen ExAC gnomAD
rs1195846111 CA393508454	373	M>V		No	ClinGen gnomAD
CA7673355 rs779070135	374	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1159960383 CA393508469	375	L>F		No	ClinGen TOPMed
CA393508486 rs1431995921	377	L>R		No	ClinGen gnomAD
CA7673358 rs370901685	378	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1193276787 CA393508494	379	G>D		No	ClinGen TOPMed
CA7673360 rs199852426	379	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs376932946 CA7673362	384	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA7673363 rs763774429	384	A>V		No	ClinGen ExAC gnomAD
rs371381699 CA7673364	385	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs371381699 CA7673365	385	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA393508529 rs1596178218	385	T>P		No	ClinGen Ensembl
CA393508535 rs141978373	386	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7673367 rs141978373	386	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7673366 rs766975266	386	S>P		No	ClinGen ExAC gnomAD
CA393508543 rs1337991378	387	E>D		No	ClinGen TOPMed
CA393508541 rs1398960267	387	E>G		No	ClinGen TOPMed
CA7673370 rs753624101	388	S>G		No	ClinGen ExAC gnomAD
CA393508551 rs1446787619	388	S>R		No	ClinGen gnomAD
CA393508553 rs1299432851	389	A>P		No	ClinGen TOPMed
CA7673371 rs201746326	391	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7673372 VAR_026880 rs937732	391	R>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs937732 CA393508566	391	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1198113887 CA393508569	392	S>G		No	ClinGen gnomAD
CA273673819 rs986003816	393	S>*		No	ClinGen Ensembl
rs1470851793 CA393508592	395	T>I		No	ClinGen gnomAD
CA393508587 rs1596178303	395	T>P		No	ClinGen Ensembl
rs965832770 CA273673822	396	R>Q		No	ClinGen TOPMed gnomAD
rs777931400 CA7673375	396	R>W		No	ClinGen ExAC TOPMed gnomAD
CA393508596 rs1194396801	397	A>T		No	ClinGen TOPMed
CA273673830 rs971975411	397	A>V		No	ClinGen gnomAD
CA393508615 rs1596178337	399	S>R		No	ClinGen Ensembl
rs1245475315 CA393508626	401	S>G		No	ClinGen TOPMed
rs1304720477 CA393508631	401	S>R		No	ClinGen gnomAD
rs201057411 CA393508652	404	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201057411 CA7673376	404	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7673379 rs759926541	405	L>P		No	ClinGen ExAC TOPMed gnomAD
rs777320679 CA7673378	405	L>V		No	ClinGen ExAC gnomAD
CA393508665 rs1241186519	407	S>A		No	ClinGen gnomAD
rs761306701 CA7673382	409	M>T		No	ClinGen ExAC TOPMed
CA393508675 rs1315608451	409	M>V		No	ClinGen TOPMed
rs767171611 CA7673383	410	D>E		No	ClinGen ExAC gnomAD
CA7673384 rs143570529	411	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA273673860 rs937888304	411	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7673385 rs760243011	412	S>R		No	ClinGen ExAC gnomAD
rs1251800762 CA393508701	412	S>R		No	ClinGen gnomAD
CA393508699 rs1222431601	412	S>T		No	ClinGen gnomAD
CA919593240 rs1567188587	413	T>M		No	ClinGen Ensembl
CA393508703 rs1596178431	413	T>P		No	ClinGen Ensembl
rs754961645 CA7673388	415	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7673389 rs373954795	415	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373954795 CA7673390	415	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA393508717 rs373954795	415	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1045911513 CA273673892	416	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7673395 rs368467428	418	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776253667 CA7673397	420	S>A		No	ClinGen ExAC gnomAD
CA393508747 rs1193010394	420	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1335439213 CA393508749	421	E>K		No	ClinGen TOPMed gnomAD
rs1459415817 CA393508758	422	P>A		No	ClinGen TOPMed
CA393508764 rs749721963	423	G>C		No	ClinGen ExAC TOPMed gnomAD
rs749721963 CA393508763	423	G>R		No	ClinGen ExAC TOPMed gnomAD
CA7673402 rs749721963	423	G>S		No	ClinGen ExAC TOPMed gnomAD
CA7673403 rs771706401	424	P>H		No	ClinGen ExAC gnomAD
CA7673404 rs772888949	425	S>P		No	ClinGen ExAC TOPMed gnomAD
CA393508779 rs1446693143	426	P>S		No	ClinGen TOPMed gnomAD
rs937733 VAR_026881 CA7673406	427	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1179041367 CA619415622	427	P>R		No	ClinGen gnomAD
rs937733 CA7673407	427	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765232679 CA7673409	428	P>L		No	ClinGen ExAC TOPMed gnomAD
rs765232679 CA393508792	428	P>R		No	ClinGen ExAC TOPMed gnomAD
COSM3401937 CA393508800 rs1185061892	430	P>S	central_nervous_system Variant assessed as Somatic; 4.665e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA273673947 rs893366145	431	S>P		No	ClinGen Ensembl
CA393508812 rs1240806259	432	Q>P		No	ClinGen TOPMed gnomAD
CA7673411 rs758310240	434	Q>*		No	ClinGen ExAC gnomAD
CA273673959 rs751784075	434	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs764391009 CA7673412	434	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA273673963 rs1028741213	435	V>A		No	ClinGen Ensembl
rs1460373618 CA393508831	435	V>M		No	ClinGen gnomAD
rs1567188745 CA393508835	436	E>K		No	ClinGen Ensembl
rs371561578 CA7673415	437	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs757584641 CA7673414	437	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs745917005 CA7673416	438	A>P		No	ClinGen ExAC TOPMed gnomAD
rs745917005 CA393508849	438	A>T		No	ClinGen ExAC TOPMed gnomAD
rs965884640 CA273673973	441	Q>*		No	ClinGen TOPMed gnomAD
rs145543210 CA7673418	441	Q>R		No	ClinGen ESP ExAC
CA393508883 rs749618248	443	L>P		No	ClinGen ExAC TOPMed gnomAD
CA7673419 rs749618248	443	L>R		No	ClinGen ExAC TOPMed gnomAD
CA7673422 rs368038771 COSM380889	448	S>L	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs368038771 CA7673423	448	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA7673425 rs759141753	449	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA393508911 rs1240946980	449	E>K		No	ClinGen gnomAD
rs775548031 CA7673428	451	P>L		No	ClinGen ExAC gnomAD
rs775548031 CA7673427	451	P>R		No	ClinGen ExAC gnomAD
CA7673426 rs765056522	451	P>S		No	ClinGen ExAC TOPMed gnomAD
rs148877983 CA7673430	452	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7673432 rs767841400	453	P>A		No	ClinGen ExAC gnomAD
rs1404251068 CA393508948	455	Q>*		No	ClinGen gnomAD
CA273674013 rs969661650	455	Q>R		No	ClinGen Ensembl
rs756255064 CA7673434	456	K>E		No	ClinGen ExAC gnomAD
CA7673435 rs145161130	456	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs915148113 CA273674020	457	A>P		No	ClinGen TOPMed
CA273674029 rs928359695	457	A>V		No	ClinGen Ensembl
rs779182339 CA393508994	458	L>F		No	ClinGen ExAC TOPMed gnomAD
rs755505555 CA7673437	458	L>S		No	ClinGen ExAC TOPMed gnomAD
rs748524275 CA7673439	459	D>H		No	ClinGen ExAC gnomAD
CA393509049 rs543853072	461	A>G		No	ClinGen 1000Genomes TOPMed gnomAD
CA393509046 rs1260669140	461	A>S		No	ClinGen TOPMed gnomAD
rs543853072 CA273674038	461	A>V		No	ClinGen 1000Genomes TOPMed gnomAD
CA393509051 COSM361810 rs1262063774	462	P>A	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1484773682 CA393509055	462	P>H		No	ClinGen TOPMed gnomAD
CA7673443 rs375411507	463	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs375411507 CA273674057	463	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA393509068 rs1596178849	463	L>P		No	ClinGen Ensembl
CA7673442 rs375411507	463	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1481366012 CA393509073	464	A>T		No	ClinGen TOPMed gnomAD
CA273674066 rs774278839	465	R>P		No	ClinGen ExAC TOPMed gnomAD
CA7673449 rs774278839	465	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7673447 rs762917837	465	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1347174585 CA393509110	466	P>H		No	ClinGen gnomAD
CA7673452 rs1555454138	467	S>R		No	ClinGen Ensembl
CA393509126 rs1163254527	467	S>T		No	ClinGen TOPMed
CA273674080 rs1041161642	468	P>L		No	ClinGen gnomAD
CA7673455 rs565252084	469	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA393509144 rs1567188958	470	G>S		No	ClinGen Ensembl
rs147646086 CA7673457	471	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1262040134 CA393509201	475	S>R		No	ClinGen TOPMed
rs755419801 CA7673461	475	S>R		No	ClinGen ExAC gnomAD
rs200554943 CA273674093	476	P>T		No	ClinGen 1000Genomes
CA7673464 rs758847948	477	E>*		No	ClinGen ExAC gnomAD
rs758847948 CA7673466	477	E>K		No	ClinGen ExAC gnomAD
rs758847948 CA7673465	477	E>Q		No	ClinGen ExAC gnomAD
rs1220196245 CA393509225	479	E>G		No	ClinGen TOPMed gnomAD
CA7673469 rs142307813	480	H>R		No	ClinGen ESP ExAC
rs1262308413 CA393509238	480	H>Y		No	ClinGen TOPMed
CA393509255 rs1488233570	481	R>G		No	ClinGen gnomAD
rs952030565 CA393509261	481	R>K		No	ClinGen TOPMed
CA273674155 rs952030565	481	R>T		No	ClinGen TOPMed
CA393509293 rs748868524	483	S>I		No	ClinGen ExAC TOPMed gnomAD
rs748868524 CA393509296	483	S>N		No	ClinGen ExAC TOPMed gnomAD
CA7673470 rs748868524	483	S>T		No	ClinGen ExAC TOPMed gnomAD
rs746862201 CA273674174	484	L>P		No	ClinGen TOPMed
rs1596179042 CA393509345	485	F>L		No	ClinGen Ensembl
CA393509333 rs1417521338	485	F>V		No	ClinGen TOPMed gnomAD
CA7673473 rs371899674	486	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7673474 rs761488660	488	K>N		No	ClinGen ExAC
CA7673476 rs772908199	490	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs771848584 CA7673475	490	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1022858116 CA273674198	494	T>I		No	ClinGen TOPMed
CA7673478 rs760880166	494	T>P		No	ClinGen ExAC TOPMed gnomAD
rs760880166 CA393509475	494	T>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	496	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs969709170 CA273674201	496	F>L		No	ClinGen gnomAD
CA7673479 rs766523878	497	Q>*		No	ClinGen ExAC gnomAD
rs981061103 CA273674204	498	I>S		No	ClinGen gnomAD
CA7673480 rs776679000	499	R>S		No	ClinGen ExAC gnomAD
CA273674205 rs145747266	499	R>T		No	ClinGen ESP
CA7673481 rs759678524	500	P>S		No	ClinGen ExAC gnomAD
rs765700338 CA7673482	502	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA273674223 rs1003226137	504	F>C		No	ClinGen TOPMed gnomAD
rs148206905 CA7673483	504	F>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA393509624 rs1307977748	505	Q>*		No	ClinGen gnomAD
TCGA novel	507	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7673486 rs751884312	508	V>G		No	ClinGen ExAC gnomAD
CA393509668 rs1234698773	508	V>L		No	ClinGen TOPMed gnomAD
rs1034716339 CA273674249	509	P>S		No	ClinGen TOPMed
rs955789282 CA273674256	510	M>T		No	ClinGen Ensembl
rs1243915686 CA393509706	511	L>R		No	ClinGen gnomAD
rs755781988 CA7673488	512	E>D		No	ClinGen ExAC gnomAD
CA7673489 rs779923079	514	K>*		No	ClinGen ExAC gnomAD
CA393509757 rs1413751828	515	F>I		No	ClinGen TOPMed gnomAD
rs376333952 CA393509775	516	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1352290788 CA393509780	516	R>T		No	ClinGen gnomAD
CA7673492 rs778584893	519	E>G		No	ClinGen ExAC gnomAD
CA7673493 rs748075707	520	S>Y		No	ClinGen ExAC gnomAD
CA393509850 rs1450238917	522	E>K		No	ClinGen TOPMed gnomAD
rs773001964 CA7673495	523	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA7673497 rs771136340	524	K>*		No	ClinGen ExAC gnomAD
CA7673498 rs776876074	525	L>P		No	ClinGen ExAC gnomAD
CA7673499 rs776876074	525	L>Q		No	ClinGen ExAC gnomAD
CA393509876 rs1305851934	526	H>Y		No	ClinGen gnomAD
CA7673500 rs765262559	527	R>K		No	ClinGen ExAC gnomAD

No associated diseases with Q2M3C6

No regional properties for Q2M3C6

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q2M3C6

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Cell projection, dendrite Perikaryon	Present in the dendrites and soma of cerebellar granule neurons, but not in their axon
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
perikaryon	The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
protein homodimerization activity	Binding to an identical protein to form a homodimer.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MAVAPSFNMT	NPQPAIEGGI	SEVEIISQQV	DEETKSIAPV	QLVNFAYRDL	PLAAVDLSTA
70	80	90	100	110	120
GSQLLSNLDE	DYQREGSNWL	KPCCGKRAAV	WQVFLLSASL	NSFLVACVIL	VVILLTLELL
130	140	150	160	170	180
IDIKLLQFSS	AFQFAGVIHW	ISLVILSVFF	SETVLRIVVL	GIWDYIENKI	EVFDGAVIIL
190	200	210	220	230	240
SLAPMVASTV	ANGPRSPWDA	ISLIIMLRIW	RVKRVIDAYV	LPVKLEMEMV	IQQYEKAKVI
250	260	270	280	290	300
QDEQLERLTQ	ICQEQGFEIR	QLRAHLAQQD	LDLAAEREAA	LQAPHVLSQP	RSRFKVLEAG
310	320	330	340	350	360
TWDEETAAES	VVEELQPSQE	ATMKDDMNSY	ISQYYNGPSS	DSGVPEPAVC	MVTTAAIDIH
370	380	390	400	410	420
QPNISSDLFS	LDMPLKLGGN	GTSATSESAS	RSSVTRAQSD	SSQTLGSSMD	CSTAREEPSS
430	440	450	460	470	480
EPGPSPPPLP	SQQQVEEATV	QDLLSSLSED	PCPSQKALDP	APLARPSPAG	SAQTSPELEH
490	500	510	520	530
RVSLFNQKNQ	EGFTVFQIRP	VIHFQPTVPM	LEDKFRSLES	KEQKLHRVPE	A