Q2LTN3

PR
Gene name
lepA
Protein name
Elongation factor 4
Names
EF-4, Ribosomal back-translocase LepA
Species
Syntrophus aciditrophicus (strain SB)
KEGG Pathway
sat:SYN_02187
EC number
3.6.5.n1: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

536-598 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2LTN3

Entry ID Method Resolution Chain Position Source
AF-Q2LTN3-F1 Predicted AlphaFoldDB

No variants for Q2LTN3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2LTN3

No associated diseases with Q2LTN3

8 regional properties for Q2LTN3

Type Name Position InterPro Accession
domain Elongation factor EFG, domain V-like 400 - 485 IPR000640
domain Translational (tr)-type GTP-binding domain 2 - 184 IPR000795
domain Translation elongation factor EFTu-like, domain 2 205 - 275 IPR004161
domain Small GTP-binding protein domain 5 - 174 IPR005225
domain GTP-binding protein LepA, C-terminal 488 - 594 IPR013842
conserved_site Tr-type G domain, conserved site 42 - 57 IPR031157
domain Elongation factor 4, domain IV 401 - 480 IPR035654
domain Elongation Factor G, domain II 292 - 363 IPR041095

Functions

Description
EC Number 3.6.5.n1 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
ribosome binding Binding to a ribosome.
translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome.

1 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDHIRNFSII AHIDHGKSTL ADRLIQFTGI SDERTFKDQM LDNMDIERER GITIKSQAIT
70 80 90 100 110 120
LPYQAKDGKT YSLNLIDTPG HVDFSYEVSR ALASCEGVLL LIDAAQGVQA QTVANLYLAM
130 140 150 160 170 180
EHNLEIIPVI NKIDLPSADV ERVIEQIDDE LGLDSEGHLK CSAKAGIGIQ DILEAIVKRV
190 200 210 220 230 240
PPPRGNPEAP LAALIFDAHY DPFRGTIIHC RIMEGTVKSG DTIRFMSNSA TYRVEEVGHF
250 260 270 280 290 300
LLQREKRNCL SAGEVGYIIA GVKTVSDVRT GDTITLDDRP CSQPLPGFRE VKPVVFASIY
310 320 330 340 350 360
PIASDDYDDL KAALEKYQLN DASFIYQKDS SAALGQGFRC GFLGLLHLEV VQERLEREYD
370 380 390 400 410 420
QSIILSVPSV RYRFTLKDGS VVYVDNPAHY PGSSSIELSE EPYIRATLML PERYLGAVMK
430 440 450 460 470 480
LCMEKRGVNS TLNYPSPGRV ELLYEMPLAE VIYDFYDRFK SVTQGYGSFD YELIDYRESQ
490 500 510 520 530 540
LVLLDILVNG ERVDALSQIV HRDRARARGL QACERLKEEI PRQMFKIAIQ GAIGGEIISR
550 560 570 580 590
TTITPFRKDV IAKCYGGDIS RKRKLLEKQK KGKKRMKMIG QVSIPQSAFL SVLKSDAD