Q2LQK5

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Syntrophus aciditrophicus (strain SB)
KEGG Pathway
sat:SYN_02374
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

249-318 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2LQK5

Entry ID Method Resolution Chain Position Source
AF-Q2LQK5-F1 Predicted AlphaFoldDB

No variants for Q2LQK5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2LQK5

No associated diseases with Q2LQK5

6 regional properties for Q2LQK5

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 421 - 580 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 610 - 654 IPR002300-2
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 698 - 823 IPR013155
domain Methionyl/Leucyl tRNA synthetase 41 - 182 IPR015413
domain Leucyl-tRNA synthetase, editing domain 221 - 407 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNRKYVPQEI EEKWQRYWEE KNTFKVTEDP SKKKYYLLEM FPYPSGKIHI GHVRNYTIGD
70 80 90 100 110 120
VVARYKRMEG YNVLHPMGWD SFGMPAENAA IERGIHPSLW TNENITHMRK QLKRMGFSYD
130 140 150 160 170 180
WDREVSTCEP VYYRWEQLFF LWMYEKGLAY KKTSSVNWCP RCQTVLANEQ VEAGLCWRCG
190 200 210 220 230 240
SEVVEKILDQ WFFRITAYID ELLAGCDRLT GWPERVLTMQ RNWIGKSYGC EVSFPMADGN
250 260 270 280 290 300
GDIKVFTTRQ DTLFGATFML IAAEHPLVME LIKGKPVEKD ARTFAEEVKK QDKLMRTSDY
310 320 330 340 350 360
YEKQGLFLDC YCLNPLTGWE MPIFATNFVL ADYGTGCVMA VPTHDQRDFE FAEKFGLRKV
370 380 390 400 410 420
VVISPPDKTL DPETMTEAYV EEGILVNSGP FNGMENLKAL DAIADHLIAL GRGKRTIQYR
430 440 450 460 470 480
LRDWGISRQR YWGAPIPMIM CPKCGTVPVP EAELPVVLPR DVDFSGEGGS PLAKHPEFLN
490 500 510 520 530 540
TTCPSCGGPA KRESDTMDTF VESSWYFERY CCPHFAEKPG LNRQQVDYWM PVDQYIGGIE
550 560 570 580 590 600
HAILHLLYAR FYTRMLRDFG LVGVDEPFTN LLTQGMVCKE TTRCPDHGYL YPEEVREGRC
610 620 630 640 650 660
IHCLAEVIVG KTEKMSKSLK NVVDPDYLVR QYGADTARMF CLFAAPPEKD LEWSDQGVEG
670 680 690 700 710 720
SFRFIGRTWR IVVDYLDDLQ GIAPFAGDGE LEGELKSLRR KTHQTIRKVR DDMGERFHFN
730 740 750 760 770 780
TAISAIMELV NTLYGLPRPP REDRTALAVI RETIEAIILL LAPIVPHLTE ELWQMLGHQG
790 800 810 820 830 840
TCLADTPLPV YDPTVAAEDE MTIVIQVNGK VRSRVIVAAD EAEDKIKALA MGDEKVSRFL
850 860
EGKSVIKQVY VPKKLVNIVV KG