Q2LA59

PR
Gene name
CYP21
Protein name
Steroid 21-hydroxylase
Names
21-OHase, Cytochrome P-450c21, Cytochrome P450 21, Cytochrome P450 XXI, Cytochrome P450-C21
Species
Lynx lynx (Eurasian lynx) (Felis lynx)
KEGG Pathway
EC number
1.14.14.16: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

442-492 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2LA59

Entry ID Method Resolution Chain Position Source
AF-Q2LA59-F1 Predicted AlphaFoldDB

No variants for Q2LA59

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2LA59

No associated diseases with Q2LA59

1 regional properties for Q2LA59

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 419 - 428 IPR017972

Functions

Description
EC Number 1.14.14.16 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Endoplasmic reticulum membrane; Peripheral membrane protein
  • Microsome membrane; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.

6 GO annotations of molecular function

Name Definition
17-hydroxyprogesterone 21-hydroxylase activity Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced = 11-deoxycortisol + H(+) + H2O + oxidized
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
progesterone 21-hydroxylase activity Catalysis of the reaction: O2 + progesterone + reduced = 21-hydroxyprogesterone + H(+) + H2O + oxidized
steroid binding Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
steroid hydroxylase activity Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.

2 GO annotations of biological process

Name Definition
steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLLGLLLLT ALAGARLLWN KWKYRSLHLP PLAPGFLHLL QPDLPIYLLG LTQKLGPVYR
70 80 90 100 110 120
LRLGLQDVVV LNSKRTIEEA MIRRWVDFAG RPQMPSYKLV SQPYQDLSLG DYSLLWKAHK
130 140 150 160 170 180
KLTRSALLLG IRNSMEPLVE QLTQEFCERM RAQAGTPVAI QKEFSFLTCS VICCLTFGDK
190 200 210 220 230 240
EDTLVHAFHD CVQDLMKSWE HWSIQVLDIV PFLRFFPNPG LQRLKQALEN RDRIVEKQLR
250 260 270 280 290 300
QHKDSMVAGQ WRDMTDYMLQ GMGKPRAEKG HGRLLEGHVH MSVVDLFIGG TETTATTLSW
310 320 330 340 350 360
AVAFLLHHPE IQQRLQEELD CELGPGASGS RVPLKDPSRL PLLTATIAEV LRLRPVVPLA
370 380 390 400 410 420
LPHRTTRHSS ILGYDIPEGT VVIPNLQGAH LDDTVWEQPH EFRPDRFLVP GASPRVLAFG
430 440 450 460 470 480
CGARVCLGEP LARLELFVVL ARLLHAFTLL PPTGPLPSLR PRSHCGINLT MQPFQVQLQP
490
RGAVAPGPSQ HQ