Q2KY72

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Bordetella avium (strain 197N)
KEGG Pathway
bav:BAV2356
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2KY72

Entry ID Method Resolution Chain Position Source
AF-Q2KY72-F1 Predicted AlphaFoldDB

No variants for Q2KY72

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2KY72

No associated diseases with Q2KY72

4 regional properties for Q2KY72

Type Name Position InterPro Accession
domain DHHA1 domain 731 - 869 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 651 - 693 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 552 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 706 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSSEIRQKF LQFFQSKGHS IVPSSSLVPG NDPTLLFTNS GMVQFKDVFT GKEKRPYTRA
70 80 90 100 110 120
TSSQRSVRAG GKHNDLENVG YTARHHTFFE MLGNFSFGDY FKQDAIRFAW ELLTTVYKLP
130 140 150 160 170 180
VEKLWVTVYQ EDDEAYDIWA KEVGVPTERI IRIGDNKGAR YASDNFWQMG DTGPCGPCTE
190 200 210 220 230 240
IFYDHGPDIW GGPPGSPEED GDRYIEIWNL VFMQFERDAA GNMTPLPKPC VDTGMGLERI
250 260 270 280 290 300
AAVLQGVHSN YEIDLFQKLI TAAARETGVQ DLHDNSLKVI ADHIRACSFL IVDGVIPSNE
310 320 330 340 350 360
GRGYVLRRIV RRALRHGYKL GQTKPFFYRL VPDLVAQMGE AYPELANMAE RVGQVLKQEE
370 380 390 400 410 420
ERFGETLEHG MKILDVALAQ VPKGGLLDGN TLFTLYDTYG FPVDLTADIC REREVEIDMA
430 440 450 460 470 480
GFEAAMERQR DQARAAGKFK MAEGLNYEGA QTRFEGYEQL ELSGAKVTAL YVDGTQTDQV
490 500 510 520 530 540
RAGQQAVVVL DATPFYAESG GQVGDTGLLV ADGLRFAVAD TLKVQAGVFG HHGLLEEGVL
550 560 570 580 590 600
KVGDTLLARV DAVRRARTVR NHSATHLMHK ALREVLGAHV QQRGSLVDPD KTRFDFAHDA
610 620 630 640 650 660
PMTAEQIARV EAIVNAEVLA NQAAQARVMA YDDAVKGGAM ALFGEKYGDT VRVLDIGFSR
670 680 690 700 710 720
ELCGGTHVSR TGDIGLFKIV SEGGVAAGVR RVEAITGDNA LVWVQEQNAL LQRAAGVLRS
730 740 750 760 770 780
PVAELPERIA QVQDQVKALE KDLEQARAKL AASAGNDLAD KSAVEIKGVK VLAAVINDVD
790 800 810 820 830 840
PKALRGMVDN LKDKLKPAIV LLAASADGKI SLVGGVTADQ TAKVKAGDLV GFVAAQVGGK
850 860 870
GGGRPDMAMG GGTDVAALPA AIASVQDWVN ERL