Q2KI89

PR
Gene name
ARMC9
Protein name
LisH domain-containing protein ARMC9
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:536462
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

612-665 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2KI89

Entry ID Method Resolution Chain Position Source
AF-Q2KI89-F1 Predicted AlphaFoldDB

No variants for Q2KI89

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2KI89

No associated diseases with Q2KI89

1 regional properties for Q2KI89

Type Name Position InterPro Accession
domain LIS1 homology motif 7 - 39 IPR006594

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, cilium basal body
  • Cell projection, cilium
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • Localized to the proximal region in cilia
  • Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity)
  • Localizes to the daughter centriole of the primary cilium in RPE1 cells (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
ciliary tip Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction.
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
positive regulation of smoothened signaling pathway Any process that activates or increases the frequency, rate or extent of smoothened signaling.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVDVLAHESE LLGLVKEYLD FAEFEDTLKT FLKECKIKGK PLSKSTCGSL RDPKSLKFQR
70 80 90 100 110 120
DLLAAFDSGD QKVFFRLWEE HIPRPIRDGD SLAQKLEFYL HIHFAIYLLK HSAGRPDKED
130 140 150 160 170 180
LDERISYFKT FLETKGAALS QTTEFLPFYA LPFVPNPMAH PSFKELFQDS WTSELKLKLE
190 200 210 220 230 240
KFLALMFKAS NTPKLLTLYK ENGQSNKDVL QQLHQQLVEA ERRSMTYLKR YNRIQADYHN
250 260 270 280 290 300
LIGVTAELVD SLEATVSGKM ITPEYLQSVC VRLFSNQMRQ SLAHSVDFTR PGTASTMLRA
310 320 330 340 350 360
SLAPVKLKDV PLLPSLDYEK LKKDLILGSD RLKAFLLQAL RWRLTTSHPG EQRETVLQAY
370 380 390 400 410 420
ISNDLLDCHS HSQRSVLQLL QSKSEVVRQY TARLINAFAS LAEGRRYLAQ STKVLRMLEE
430 440 450 460 470 480
RLKEEDKDVI TRENVLGALQ KFSLRRPLQT AMIQDGLIFW LIDILKEPDC LSDYTLEYSV
490 500 510 520 530 540
ALLMNLCLRS AGKNMCAKVA GLVLKVLSDL LGHENHEIQP YVNGALYSIL SIPSIREEAR
550 560 570 580 590 600
AMGMEDILRC FIKEGNAEMI RQIEFIIKQL NAEELLDGVL ESDDDEDEDD EEDHDTMEAD
610 620 630 640 650 660
LDKDELIQPQ LGELSGEKLL TTEYLGIMTN TGKARRRGTA GVQWGGPEPL RRPVTPGGHR
TGYPA