Q2KHP8

PR
Gene name
tyw1 (rsafd1)
Protein name
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1
Names
Radical S-adenosyl methionine and flavodoxin domain-containing protein 1, tRNA wybutosine-synthesizing protein 1 homolog, tRNA-yW-synthesizing protein
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:735035
EC number
4.1.3.44: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

23-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2KHP8

Entry ID Method Resolution Chain Position Source
AF-Q2KHP8-F1 Predicted AlphaFoldDB

No variants for Q2KHP8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2KHP8

No associated diseases with Q2KHP8

7 regional properties for Q2KHP8

Type Name Position InterPro Accession
domain Flavodoxin-like 84 - 97 IPR001094-1
domain Flavodoxin-like 137 - 148 IPR001094-2
domain Flavodoxin-like 175 - 185 IPR001094-3
domain Flavodoxin-like 200 - 219 IPR001094-4
domain Radical SAM 403 - 649 IPR007197
domain Flavodoxin/nitric oxide synthase 83 - 241 IPR008254
domain tRNA wybutosine-synthesis 598 - 660 IPR013917

Functions

Description
EC Number 4.1.3.44 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
metal ion binding Binding to a metal ion.
tRNA-4-demethylwyosine synthase activity Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe.

1 GO annotations of biological process

Name Definition
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDKSTDAWDF AYTHLMFLWL NRFYIYSCAA IGITVWVCSH FIMARKKHQN ETVCNGSLLL
70 80 90 100 110 120
KTKALKSDSL TSNKEQKVYV AGVKIFYGSQ TGTSKGFAHL LAEEVTLLGL PVELINMKEY
130 140 150 160 170 180
DPDDNLVEET TSKNICVFLV ATYTDGKPPE SAEWFCKWLE EASNDFRFGK TYLKGMRYAV
190 200 210 220 230 240
FGLGNSVYST HYNTVGKNID KWLWMLSANR VMTRAEGDCN VVKSKHGSIE SDFEAWKRKF
250 260 270 280 290 300
LNRLKALLSG EKKPCSGKCK KGKCKSKKKS SIESVEEEEE EEEKHSEHED TEDDTFETSS
310 320 330 340 350 360
DSEPEEHGEP GSGLIDVEDL GKAMSNMKKS KREHDSNTEL GKSLQGDEAK EKEEPREMIT
370 380 390 400 410 420
PALQEALTKQ GYRLIGSHSG VKLCRWTKSM LRGRGGCYKH TFYGIESHRC METTPSLACA
430 440 450 460 470 480
NKCVFCWRHH TNPVGTEWRW KMDQPEMILE EAILNHQNMI KQFKGVPGVK PERFEEGLAV
490 500 510 520 530 540
KHCALSLVGE PIMYPEINTF LRLLHNQHIS SFLVTNAQFP EEIRSLEPVT QLYVSVDAST
550 560 570 580 590 600
KDSLKKIDRP LFKDFWQRFI DSLKALAEKQ QRTVYRLTLV KAWNVDELKA YADLVALGLP
610 620 630 640 650 660
DFIEVKGVTY CGESSASNLT MANVPWHEEV IRFVEELVDL LPDYEVACEH EHSNCMLIAH
670 680 690 700 710 720
KKFKINGEWC TWIDYERFQE LIQAFGESKG SRTFTALDYV AKTPEWALFG SRERGFDPLD
730
KRFQRKNKTK DISGC