Q2K9E5
Gene name |
hmgA |
Protein name |
Homogentisate 1,2-dioxygenase |
Names |
HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase |
Species |
Rhizobium etli (strain CFN 42 / ATCC 51251) |
KEGG Pathway |
ret:RHE_CH01746 |
EC number |
1.13.11.5: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2K9E5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2K9E5-F1 | Predicted | AlphaFoldDB |
No variants for Q2K9E5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2K9E5 | |||||
No associated diseases with Q2K9E5
1 regional properties for Q2K9E5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain | 12 - 324 | IPR041715 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.5 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| homogentisate 1,2-dioxygenase activity | Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). |
| iron ion binding | Binding to an iron (Fe) ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| L-phenylalanine catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. |
| tyrosine catabolic process | The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQTAIQAAD | AEAATANRLK | YMPGFGNDFE | TESLPGALPQ | GQNSPQKCNY | GLYAEQLSGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PFTAPRGTNE | RSWLYRIRPS | VRHTRRFSNA | SYPLWKTAPC | LDEHSLPLGQ | LRWDPIPAPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKLTFLQGVR | TMTTAGDAAT | QVGMSAHAYV | FNEDMVDDYF | FDADGELLIV | PQLGAIRVFT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EMGIMDVEPL | EICLVPRGMM | FKVMTTGEQT | ASRGYICENY | GAKFTLPDRG | PIGANCLANP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RDFKTPVAAF | EDKEKPCRVH | VKWCGKFYVT | EIGHSPLDVV | AWHGNYAPYK | YDLRTFSPVG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AISFDHPDPS | IFSVLTAPTE | DAGTANVDFV | IFPPRWLVAE | HTFRPPWYHR | NIMSEFMGLI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HGQYDAKEEG | FVPGGISLHN | MMLPHGPDAL | AFEKASNVEL | KPVKLDHTMA | FMFETRYPQQ |
| 430 | 440 | 450 | |||
| LTKYAAELET | LQDDYLECWD | GLERKFDGTP | GIK |