Q2JTG8

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
KEGG Pathway
cya:CYA_1881
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

385-471 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2JTG8

Entry ID Method Resolution Chain Position Source
AF-Q2JTG8-F1 Predicted AlphaFoldDB

No variants for Q2JTG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2JTG8

No associated diseases with Q2JTG8

5 regional properties for Q2JTG8

Type Name Position InterPro Accession
domain DHHA1 domain 733 - 872 IPR003156
domain Aminoacyl-tRNA synthetase, class II 62 - 248 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 696 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 10 - 553 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 5 - 709 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSPSFSGAAI RQAFLDFYAQ RGHQVLPSAS LVPEDPTVLL TIAGMLPFKP IFLGHQDPQY
70 80 90 100 110 120
PRVTTAQKCV RTNDIENVGR TARHHTFFEM LGNFSFGDYF KKEAITWAWE LVTEVFGLPP
130 140 150 160 170 180
ERLVVSVFRE DEEAFALWRD AIGIPPHRIR RMGEEDNFWA AGPTGPCGPC SEIYYDFKPE
190 200 210 220 230 240
LGDEQIDLGD DSRFLEIYNL VFMELNRDSE GRLTPLARQN IDTGLGLERL AQVLQGVPNN
250 260 270 280 290 300
YETDLIFPIV QKAAEIARVD YFQASPEQKV SLKVIGDHAR AVMHLIADGV IPSNVDRGYV
310 320 330 340 350 360
LRRLIRRMVR HGRLLGIGEP FTLPVVETAI QLAEAAYPEV REREAVIKAE LQREEEQFLK
370 380 390 400 410 420
TLERGERLLF DLFANVTASG APKQISGADA FKLFDTYGFP LELTQEIAQE RGFSVDVQGF
430 440 450 460 470 480
EQEMEKQRQR ARAAHQTLDV TAQGSLDELA EFLIETEFLG YSQSSARGVV EALLVEGKSV
490 500 510 520 530 540
PQVEAGQSVQ VVLDRTPFYA ESGGQIGDRG YLAGDGVLVR VEDVQKRGDL FVHFGWVERG
550 560 570 580 590 600
ILRVGDPVQA QIDLACRRRA QAHHTATHLL QAALKKVVDP SISQAGSLVA FDRLRFDFTL
610 620 630 640 650 660
SRPLTPEELQ QVEDLVNTWI AEAHPAQVSI MPLAEAKARG AIAMFGEKYG AEVRVVDFPG
670 680 690 700 710 720
VSMELCGGTH VSNTAEIGLF KIISESGVAA GIRRIEAVAG PAVLEYLNER DSVVRELSAQ
730 740 750 760 770 780
FKAKPQEIPE RVAALQAELK AAQRALEEAR SQLALLQAER LLPQAVAVGN LQILAAELGS
790 800 810 820 830 840
TPPEALKTAA EHLLHKLGEG AVVLGSVPEA GKVSLVAAFS PAVQKLGLKA GSFIGEIAKL
850 860 870 880
TGGGGGGRPN LAQAGGKQPE KLAQALQVAQ ERLQAELSSG LGS