Q2JMD8

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
KEGG Pathway
cyb:CYB_1126
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

212-291 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2JMD8

Entry ID Method Resolution Chain Position Source
AF-Q2JMD8-F1 Predicted AlphaFoldDB

No variants for Q2JMD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2JMD8

No associated diseases with Q2JMD8

6 regional properties for Q2JMD8

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 101 - 491 IPR002314
domain Anticodon-binding 508 - 600 IPR004154
domain Aminoacyl-tRNA synthetase, class II 37 - 514 IPR006195
domain YbaK/aminoacyl-tRNA synthetase-associated domain 265 - 408 IPR007214
domain Prokaryote proline-tRNA ligase core domain 21 - 224 IPR033730
domain Proline--tRNA ligase, anticodon binding domain 506 - 598 IPR044140

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQQSQRLSQM LFVTLREDPV EAELPSHKLL LRGCFIRRLS PGIYTYLPLL WRVLQKISEI
70 80 90 100 110 120
VRQEMNAIGG QECLLPQLQP AEIWRESGRW DVYTQAEGIM FALKDRQGRE QSLGPTHEEV
130 140 150 160 170 180
ITLLARDLIR SYRQLPQTLY QIQTKFRDEI RPRFGLMRGR EFIMKDAYSF HANEESLRQT
190 200 210 220 230 240
YQDMYRAYSR ILRRCGLEFR VVDADAGAIG GPSAASQEFM VLASAGEDEI LYTPDGSYAA
250 260 270 280 290 300
NVEKAVSIPP PAAESPYTAF QVLDTPGTET IEKLAAFLKI SSTLIVKNVL YQALYDNGLR
310 320 330 340 350 360
VAVLLSIRGD QEVNEVKLAN HLSRLAERYQ ASKLLKLALA DAEIQNSWQG DPIPVGYIAP
370 380 390 400 410 420
DLPDSCLGRQ KNLAPQILRL ADQTAALLQN FVTGGNQVGQ HVVGANWGEQ YPLPEVVDVR
430 440 450 460 470 480
KAQAGDRCLL NPDQILETAR GIEIGHIFQL GLKFSLPMRA TFTDEQGSEQ PLWMGCYGIG
490 500 510 520 530 540
VSRLAQAAVE QSHDANGIIW PVAIAPYHVV VVVPNISDPE QMSVAEKLVQ DLATAGIETL
550 560 570 580 590 600
WDDRDERAGV KFKDADLIGI PYRITTGRSL KQGKVELTER ASGQATEIPI EEVVTTLKER
IEAALAVPD