Q2JLC4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
KEGG Pathway
cyb:CYB_1521
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

344-484 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2JLC4

Entry ID Method Resolution Chain Position Source
AF-Q2JLC4-F1 Predicted AlphaFoldDB

No variants for Q2JLC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2JLC4

No associated diseases with Q2JLC4

4 regional properties for Q2JLC4

Type Name Position InterPro Accession
domain DHHA1 domain 737 - 876 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 657 - 700 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 10 - 557 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 5 - 713 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFPALSGAAI RQTFLDFYAQ RGHQVLPSAS LVPEDPTVLL TIAGMLPFKP IFLGQRDPEY
70 80 90 100 110 120
PRVTTAQKCV RTNDIENVGR TARHHTFFEM LGNFSFGDYF KKEAIAWAWE LVTEVFGLPP
130 140 150 160 170 180
ERLVVSVFRE DEEAFALWRD EIGIPAHRIQ RMGEADNFWA AGPTGPCGPC SEIYYDFKPE
190 200 210 220 230 240
LGDERIDLED DSRFLEIYNL VFMELNRDSE GHLMPLAKQN IDTGLGLERL AQVLQGVPNN
250 260 270 280 290 300
YETDLIFPII QTAAGIAGLN YSKANPEQQI SLKVIGDHAR AVMHLIADGV LPSNVDRGYV
310 320 330 340 350 360
LRRLIRRMVR HGRLLGIGEP FTIPVIETAI QLAEAAYPQV RERETLIKTE LQREEEQFLK
370 380 390 400 410 420
TLERGERLLL DLFTAVESSR RDSSSPKQIS GADAFKLFDT YGFPLELTQE IAQEHGFSVD
430 440 450 460 470 480
LEGFEQEMEK QRQRARAAHQ TIDLTAQGSL DELADFLSQT EFLGYSQSSA RGVVEALLVE
490 500 510 520 530 540
GKSVPQVEAG QAVQVVLDRT PFYAEAGGQI GDRGYLSGDG LLVRIEDVQK QGDLFVHFGR
550 560 570 580 590 600
VERGILRVGD PVQAQIDLAC RRRAQAHHTA THLLQAALKR IVDPSIGQAG SLVAFDRLRF
610 620 630 640 650 660
DFTLSRPVTP EELEQIENLV NTWIAEAHAA QVAIMPLAEA KARGAVAMFG EKYGAEVRVI
670 680 690 700 710 720
DFPGVSMELC GGTHVNNTAE IGLFKIIAET GVAAGIRRIE AVAGPAVLEY LNERDRVVRE
730 740 750 760 770 780
LSAQFKAKPQ ELPERVAALQ AELKAAQKEL EEVRSQLALL QAEGLLAQAV AVADLKVLVA
790 800 810 820 830 840
ELGSTTPEAL KTAAEHLLHK LGEGAVVLGS VPEAGKVSLV AAFSPAVQQL GLKAGSFIGE
850 860 870 880
IAKLTGGGGG GRPNLAQAGG KQPEKLAEAL QVARERLQAE LISR